RT Journal Article
T1 Scrutinizing the triad of Vibrio tapetis, the skin barrier and pigmentation as determining factors in the development of skin ulcerations in wild common dab (Limanda limanda)
A1 Vercauteren, Maaike
A1 Swaef, Evelien De
A1 Declercq, Annelies M.
A1 Polet, Hans
A1 Aerts, Johan
A1 Ampe, Bart
A1 López Romalde, Jesús
A1 Haesebrouck, Freddy
A1 Devriese, Lisa
A1 Decostere, Annemie
A1 Chiers, Koen
AB Recently, Vibrio tapetis was isolated for the first time from skin ulcerations in wild-caught common dab (Limanda limanda). To further examine its role in the development of these skin lesions, an in vivo experiment was performed. The significance of the skin barrier and in addition the difference between pigmented and non-pigmented side were investigated. Hence, the skin of common dab was treated in three different ways on both the pigmented and non-pigmented side. On a first “treatment zone”, the scales and overlying epidermal tissue were removed whereas in a second zone only the mucus was discarded. The third zone served as a non-treated zone. Thereafter, fish were challenged with V. tapetis. The control group was sham treated. Mortality, clinical signs, severity and size of the developing lesions were recorded. All animals were sacrificed and sampled 21 days post-inoculation. Significantly more fish of the group challenged with V. tapetis died compared to the control group with the highest incidence occurring 4 days post-inoculation. Fish challenged with V. tapetis developed more severe skin ulcerations. In zones where scales and epidermal tissue were removed, the ulcerations were more severe compared to zones where only mucus was eliminated. Ulcerations occurred more frequently, were more severe and larger on the pigmented side. Our data represents prove of V. tapetis as causative agent of ulcerative skin lesions although prior damage of the skin seems to be a major contributing factor. Furthermore, the pigmented side seemed predisposed to the development of skin ulcerations.
PB BMC
SN 0928-4249
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21464
UL http://hdl.handle.net/10347/21464
LA eng
NO Vercauteren, M., De Swaef, E., Declercq, A.M. et al. Scrutinizing the triad of Vibrio tapetis, the skin barrier and pigmentation as determining factors in the development of skin ulcerations in wild common dab (Limanda limanda). Vet Res 50, 41 (2019). https://doi.org/10.1186/s13567-019-0659-6
NO The research was funded by the European Fisheries Fund (EVF-project VIS/15/A03/DIV), the Flemish Government and the Research Foundation—Flanders (FWO). This work makes use of resources, facilities and/or services provided by UGent and Flanders Marine Institute as part of the Belgian contribution to EMBRC-ERIC
DS Minerva
RD 29 abr 2026