RT Journal Article
T1 Relationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Study
A1 Llorente Cantarero, Francisco Jesús
A1 Aguilar Gómez, Francisco Javier
A1 Leis Trabazo, María Rosaura
A1 Bueno, Gloria
A1 Rupérez, Azahara I.
A1 Anguita Ruiz, Augusto
A1 Vázquez Cobela, Rocío
A1 Mesa, María Dolores
A1 Moreno Aznar, Luis A.
A1 Gil, Ángel
A1 Aguilera, María Concepción
A1 Gil Campos, Mercedes
K1 Pysical activity
K1 Accelerometry
K1 Oxidative stress
K1 Plasma total antioxidant capacity
K1 8-hydroxy-2′-deoxyguanosine
K1 Isoprostane F2α
AB The World Health Organization has recommended performing at least 60 min a day of moderate-to-vigorous physical activity (MVPA) and reducing sedentarism in children and adolescents to offer significant health benefits and mitigate health risks. Physical fitness and sports practice seem to improve oxidative stress (OS) status during childhood. However, to our knowledge, there are no data regarding the influence of objectively-measured physical activity (PA) and sedentarism on OS status in children and adolescents. The present study aimed to evaluate the influence of moderate and vigorous PA and sedentarism on OS and plasma total antioxidant capacity (TAC) in a selected Spanish population of 216 children and adolescents from the GENOBOX study. PA (light, moderate, and vigorous) and sedentarism (i.e., sedentary time (ST)) were measured by accelerometry. A Physical Activity-Sedentarism Score (PASS) was developed integrating moderate and vigorous PA and ST levels. Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and isoprostane F2α (F2-IsoPs), as markers of OS, were determined by ELISA; and TAC was estimated by colorimetry using an antioxidant kit. A higher PASS was associated with lower plasma TAC and urinary 8-OHdG and F2-IsoPs, showing a better redox profile. Reduced OS markers (8-OHdG and F2-IsoPs) in children with higher PASS may diminish the need of maintaining high concentrations of antioxidants in plasma during rest to achieve redox homeostasis
PB MDPI
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26216
UL http://hdl.handle.net/10347/26216
LA eng
NO Antioxidants 2021, 10(2), 320; https://doi.org/10.3390/antiox10020320
NO This research was funded by the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) (PI11/02042, PI11/02059, PI11/01425; PI16/00871, PI16/01301, PI16/01205) and RETIC (Redes temáticas de investigación cooperativa) (Red SAMID RD12/0026/0015). The authors also acknowledge Instituto de Salud Carlos III for personal funding of A.A.R: Contratos i-PFIS: doctorados IIS-empresa en ciencias y tecnologías de la salud de la convocatoria 2017 de la Acción Estratégica en Salud 2013–2016 (IFI17/00048). Á.G. was funded by the Research Plan of the Vice-Rectorate of Research and Transfer of the University of Granada, Spain This paper will be included in F.J.A. doctorate, under the “Biomedicine Program” at the University of Córdoba, Spain
DS Minerva
RD 24 abr 2026