RT Book,_Section T1 Toxicological studies with cells A1 Vale González, María del Carmen A1 Raposo García, Sandra A2 Botana López, Luis Miguel K1 Cytotoxicity K1 In vitro K1 Nneuronal cultures K1 Immunocytochemistry K1 MTT K1 Western blot AB Cell culture provides a model system that provides direct access and evaluation of the effects of chemicals on tissues and constitutes a valuable tool to analyze cell toxicity mechanisms. In vitro model systems, in general, have been used to study the mechanism of action of chemical and to analyze the cellular basis for chemicals-induced toxicity as well as to develop rapid and high throughput screening systems for the evaluation of the toxicity of chemicals, which may complement in vivo toxicity testing or may replace some in vivo models if scientifically validated and accepted by regulatory agencies. PB De Gruyter SN 9783111014449 YR 2024 FD 2024 LK https://hdl.handle.net/10347/46861 UL https://hdl.handle.net/10347/46861 LA eng NO Vale, Carmen and Raposo-García, Sandra. "5 Toxicological studies with cells". Environmental Toxicology: Non-bacterial Toxins, edited by Luis M. Botana, Berlin, Boston: De Gruyter, 2024, pp. 135-170. https://doi.org/10.1515/9783111014449-005 DS Minerva RD 6 may 2026