RT Journal Article
T1 Clinical Utility of LCT Genotyping in Children with Suspected Functional Gastrointestinal Disorder
A1 Couce Pico, María Luz
A1 Sánchez Pintos, Paula
A1 González Vioque, Emiliano
A1 Leis Trabazo, María Rosaura
K1 Lactose intolerance
K1 Lactose malabsorption
K1 C/T-13910 polymorphism
K1 Functional gastrointestinal disorders
AB Genetic testing is a good predictor of lactase persistence (LP) in specific populations but its clinical utility in children is less clear. We assessed the role of lactose malabsorption in functional gastrointestinal disorders (FGID) in children and the correlation between the lactase non-persistence (LNP) genotype and phenotype, based on exhaled hydrogen and gastrointestinal symptoms, during a hydrogen breath test (HBT). We also evaluate dairy consumption in this sample. We conducted a 10-year cross-sectional study in a cohort of 493 children with suspected FGID defined by Roma IV criteria. Distribution of the C/T-13910 genotype was as follows: CC, 46.0%; TT, 14.4% (LP allele frequency, 34.1%). The phenotype frequencies of lactose malabsorption and intolerance were 36.3% and 41.5%, respectively. We observed a strong correlation between genotype and both lactose malabsorption (Cramér’s V, 0.28) and intolerance (Cramér’s V, 0.54). The frequency of the LNP genotype (p = 0.002) and of malabsorption and intolerance increased with age (p = 0.001 and 0.002, respectively). In 61% of children, evaluated dairy consumption was less than recommended. No association was observed between dairy intake and diagnosis. In conclusion, we found a significant correlation between genotype and phenotype, greater in older children, suggesting that the clinical value of genetic testing increases with age
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23513
UL http://hdl.handle.net/10347/23513
LA eng
NO Couce, M.L.; Sánchez-Pintos, P.; González-Vioque, E.; Leis, R. Clinical Utility of LCT Genotyping in Children with Suspected Functional Gastrointestinal Disorder. Nutrients 2020, 12, 3017
DS Minerva
RD 28 abr 2026