RT Dissertation/Thesis
T1 New designs of peptidic and polymeric vectors for protein and gene delivery
A1 Juanes Carrasco, Marisa
K1 Cell-penetrating peptides
K1 Polyhydrazones
K1 Supramolecular chemistry
K1 Amphiphiles
AB The expansion of new therapeutic technologies is limited by the effective, selective and controlled transport and release of the corresponding biomolecules to the different tissues, cells and organelles. Therefore, there is a need to develop conceptually new strategies to transport and deliver proteins or nucleic acids inside cells. In this regard, in this PhD thesis, we present the development of novel cell-penetrating peptides and polymeric platforms based on amphipathic scaffolds, which are decorated with functional reactive moieties for enhaced specificity and tunability using dynamic covalent bonds such as alkoxyamines or hydraones. These new vectors were employed  in the delivery of proteins, such as lectins and Cas 9 for CRISPR technology, and challenging nucleic acids such as mRNA, following a fully supramolecular strategy.
YR 2019
FD 2019
LK http://hdl.handle.net/10347/20531
UL http://hdl.handle.net/10347/20531
LA eng
DS Minerva
RD 4 may 2026