RT Journal Article
T1 Ocular biodistribution studies using molecular imaging
A1 Castro Balado, Ana
A1 Mondelo García, Cristina
A1 González Barcia, Miguel
A1 Zarra Ferro, Irene
A1 Otero Espinar, Francisco Javier
A1 Ruibal Morell, Álvaro
A1 Aguiar Fernández, Pablo
A1 Fernández Ferreiro, Anxo
K1 Ocular biodistribution
K1 Ocular permanence
K1 Molecular imaging
K1 PET
K1 SPECT
K1 MRI
AB Classical methodologies used in ocular pharmacokinetics studies have difficulties to obtain information about topical and intraocular distribution and clearance of drugs and formulations. This is associated with multiple factors related to ophthalmic physiology, as well as the complexity and invasiveness intrinsic to the sampling. Molecular imaging is a new diagnostic discipline for in vivo imaging, which is emerging and spreading rapidly. Recent developments in molecular imaging techniques, such as positron emission tomography (PET), single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI), allow obtaining reliable pharmacokinetic data, which can be translated into improving the permanence of the ophthalmic drugs in its action site, leading to dosage optimisation. They can be used to study either topical or intraocular administration. With these techniques it is possible to obtain real-time visualisation, localisation, characterisation and quantification of the compounds after their administration, all in a reliable, safe and non-invasive way. None of these novel techniques presents simultaneously high sensitivity and specificity, but it is possible to study biological procedures with the information provided when the techniques are combined. With the results obtained, it is possible to assume that molecular imaging techniques are postulated as a resource with great potential for the research and development of new drugs and ophthalmic delivery systems
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21390
UL http://hdl.handle.net/10347/21390
LA eng
NO Castro-Balado, A.; Mondelo-García, C.; González-Barcia, M.; Zarra-Ferro, I.; Otero-Espinar, F.J.; Ruibal-Morell, Á.; Aguiar, P.; Fernández-Ferreiro, A. Ocular Biodistribution Studies Using Molecular Imaging. Pharmaceutics 2019, 11, 237
NO This work was partially supported by Instituto de Salud Carlos III-ISCIII (PI17/00940) and (RETICS Oftared, RD16/0008/0003 and RD12/0034/0017) cofunded by FEDER. It was also supported by Fundación Española de Farmacia Hospitalaria (FEFH 18-19). A.F.-F. and C.M.G. acknowledges the support of ISCIII by research grants (JR18/00014 and CM18/00090). P.A. acknowledges the support of MICINN Ramon y Cajal RYC-2015-17430 (PA)
DS Minerva
RD 24 abr 2026