RT Journal Article
T1 Palladium-Catalyzed, Enantioselective Formal Cycloaddition between Benzyltriflamides and Allenes: Straightforward Access to Enantioenriched Isoquinolines
A1 Vidal Pereira, Xandro
A1 Mascareñas Cid, José Luis
A1 Gulías Costa, Moisés
AB Benzyl and allyltriflamides can engage in Pd-catalyzed oxidative (4+2) annulations with allenes, to produce highly valuable tetrahydroisoquinoline or dihydropyridine skeletons. The reaction is especially efficient when carried out in the presence of designed N-protected amino acids as metal ligands. More importantly, using this type of chiral ligands, it is possible to perform desymmetrizing, annulative C–H activations of prochiral diarylmethylphenyl amides, and thus obtain the corresponding isoquinolines with high enantiomeric ratios
PB American Chemical Society
SN 0002-7863
YR 2019
FD 2019
LK http://hdl.handle.net/10347/18734
UL http://hdl.handle.net/10347/18734
LA eng
NO Vidal, X., Mascareñas, J., & Gulías, M. (2019). Palladium-Catalyzed, Enantioselective Formal Cycloaddition between Benzyltriflamides and Allenes: Straightforward Access to Enantioenriched Isoquinolines. J. Am. Chem. Soc., 141 (5), pp 1862–1866. doi: 10.1021/jacs.8b12636
NO This work has received financial support from Spanish grants (SAF2016-76689-R, CTQ2016-77047-P and FPU fellowship to X.V.), the Consellería de Cultura, Educación e Ordenación Universitaria (ED431C 2017/19, 2015-CP082 and Centro Singular de Investigación de Galicia accreditation 2016-2019, ED431G/09), the European Regional Development Fund (ERDF), and the European Research Council (Advanced Grant No. 340055)
DS Minerva
RD 4 may 2026