RT Journal Article
T1 Blood eosinophil count as predictor of asthma exacerbation. A meta-analysis
A1 Mallah, Narmeen
A1 Rodríguez Segade, Santiago
A1 González Barcala, Francisco Javier
A1 Takkouche, Bahi
K1 Asthma exacerbation
K1 Blood eosinophils
K1 Meta-analysis
AB BackgroundEvidence about the association of high blood eosinophil count with asthma exacerbation is inconsistent and unclear. The objective of this meta-analysis was to determine whether elevated blood eosinophil count predicts asthma exacerbation.MethodsWe searched MEDLINE, EMBASE, and additional databases, without any language restriction. We also checked the reference lists of the included studies and of relevant systematic reviews. The main outcome was the occurrence of asthma exacerbation. We calculated global pooled odds ratios (ORs) and their 95% confidence intervals (CIs) and performed predefined subgroup analyses. We appraised the quality of the studies using Newcastle-Ottawa Scale, examined the heterogeneity between studies, assessed publication bias, and carried out sensitivity analyses.ResultsAmong 1567 retrieved publications, 23 observational studies comprising 155,772 participants met the inclusion criteria. High blood eosinophil count was associated with higher odds of asthma exacerbation [OR: 1.31 (95% CI: 1.16, 1.49)], specifically with asthma-related outpatient visits [OR: 1.46 (95% CI: 1.25, 1.70)] and emergency department visits [OR: 1.63 (95% CI: 1.29, 2.07)]. A significant association was observed starting from an eosinophils’ cutoff value of 200 cells/μl. The association was observed for cohort studies [OR: 1.30 (95%CI: 1.13, 1.49)], North American studies [OR: 1.43 (95%CI: 1.31, 1.57)], Asian populations [OR: 1.67 (95%CI: 1.34, 2.08)], children [OR: 1.38 (95%CI: 1.22, 1.56)], and studies that adjusted for inhaled corticosteroids therapy [OR: 1.42 (95%CI: 1.28, 1.56)].ConclusionsBlood eosinophil counts ≥ 200 cells/µL are associated with asthma exacerbation. Blood eosinophil count is a modifiable factor that could be addressed in asthma management strategies.
PB Wiley
YR 2021
FD 2021-04-01
LK http://hdl.handle.net/10347/32837
UL http://hdl.handle.net/10347/32837
LA eng
NO Pediatric Allergy and Immunology (PAI), 32(3), pp. 465-478
NO This is the peer reviewed version of the following article: Mallah, N., Rodríguez-Segade, S., González-Barcala, F.-J., Takkouche, B. (2021). Blood eosinophil count as predictor of asthma exacerbation. A meta-analysis. PAI, 32(3), pp. 465-478, which has been published in final form at https://doi.org/10.1111/pai.13403. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
DS Minerva
RD 29 abr 2026