RT Dissertation/Thesis
T1 Electrospun mats for drug repositioning: Antimicrobial and antitumor applications
A1 González Prada, Iago
K1 Electrospinning
K1 essential oil
K1 repurposing
K1 antimicrobial
K1 antitumor
AB This PhD Thesis focuses on developing alternative approaches for treating two major societal challenges: antimicrobial resistance and cancer, with a particular emphasis on glioblastoma. To address these issues, a range of electrospun mats were prepared. Various essential oils namely carvacrol, citronellol, and cinnamic acid displaying antimicrobial, anti-inflammatory, and angiogenic properties were evaluated for treating infected chronic wounds. Additionally, the repurposed drug disulfiram was encapsulated to leverage its anticancer and antimicrobial properties in the presence of selective amounts of CuII, forming the CuDDC2 complex that enhanced the activity and reduced the toxicity. Cyclodextrins such as alpha-CD and HP-beta-CD were used to encapsulate these active compounds, improving their poor physicochemical properties and tuning the release profiles. This work highlights the advantages and versatility of the electrospinning technique in producing fiber-based scaffolds for biomedical applications.
YR 2025
FD 2025
LK https://hdl.handle.net/10347/40351
UL https://hdl.handle.net/10347/40351
LA eng
DS Minerva
RD 28 abr 2026