RT Journal Article
T1 Laser-induced transient skin disruption to enhance cutaneous drug delivery
A1 Río Sancho, Sergio del
A1 Pan Delgado, Diego
A1 Fuente, Germán F. de la
A1 García-Caballero Parada, Tomás
A1 Taboada Suárez, Antonio
A1 Csaba, Noemi Stefania
A1 Bao Varela, María del Carmen
A1 Alonso Fernández, María José
K1 Assisted delivery
K1 Confined ablation
K1 Diclofenac
K1 DiD
K1 FITC
K1 Lidocaine
K1 Resonant Amplitude Waves
K1 Steel
AB The use of pressure waves (PW) to disrupt the stratum corneum (SC) temporarily is an effective strategy to increase the deposition of drug molecules into the skin. However, given the rather modest outcomes when compared with ablation-assisted drug delivery, its potential has been underestimated. Accordingly, the aim of this study was to examine the impact of Resonant Amplitude Waves (RAWs) on increasing cutaneous delivery. RAW phenomena are triggered by focusing a high-peak-power pulsed laser onto an appropriate transducer structure, under space- and time-controlled resolution.In order to determine the optimal conditions for the generation and use of RAWs, a screening of laser parameters setting and an analysis of different geometries of the impact pattern over diverse materials used as transducers was performed, analyzing the footprint of the RAW waves in an agarose gel. The results obtained were then checked and fine-tuned using human skin samples instead of agarose. Furthermore, ex vivo experiments were carried out to characterize the effect of the RAWs in the cutaneous delivery of diclofenac (DIC) and lidocaine (LID) administered in the form of gels. The application of RAWs resulted in an increased delivery of DIC and LID to the skin, whose intensity was dependent on the composition of the formulation. In fact, the maximum observed for DIC and LID in short-time experiments (39.1 ± 11.1 and 153 ± 16 µg/cm2 , respectively) was comparable to those observed using ablation-assisted drug delivery under the same conditions. In conclusion, the combination of RAWs with specific formulation strategies is a feasible alternative for the cutaneous delivery of drug candidates when short onset of action is required.
PB Elsevier
SN 0939-6411
YR 2020
FD 2020-09-03
LK https://hdl.handle.net/10347/44236
UL https://hdl.handle.net/10347/44236
LA eng
NO Río-Sancho, S. del, Pan Delgado, D., de la Fuente, G. F., García-Caballero, T., Taboada-Suárez, A., Csaba, N., . . . José Alonso, M. (2020). Laser-induced transient skin disruption to enhance cutaneous drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 156, 165–175. doi:10.1016/j.ejpb.2020.08.027
DS Minerva
RD 23 may 2026