RT Journal Article
T1 Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides
A1 Bouzada Reboredo, David
A1 Salvadó, Iria
A1 Barka, Ghofrane
A1 Rama, Gustavo
A1 Martínez Costas, José Manuel
A1 Lorca, Romina
A1 Somoza, Álvaro
A1 Melle-Franco, Manuel
A1 Vázquez Sentís, Marco Eugenio
A1 Vázquez López, Miguel
AB A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding preference for DNA G-quadruplex structures over those lacking it, and also that the interplay between the octoarginine functionalization and the ancillary ligand in the complex has an essential role in the recognition process. Furthermore, the oligoarginine metallopeptides are also efficiently internalized, causing cell death with signs of apoptosis
PB Royal Society of Chemistry
SN 1359-7345
YR 2018
FD 2018
LK http://hdl.handle.net/10347/17024
UL http://hdl.handle.net/10347/17024
LA eng
NO Bouzada, D., Salvadó, I., Barka, G., Rama, G., Martínez-Costas, J., & Lorca, R. et al. (2018). Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides. Chemical Communications, 54(6), 658-661. doi: 10.1039/c7cc08286j
NO Financial support from the Spanish grants CTQ2015-70698-R, BFU2013-43513-R and SAF2014-56763-R, the Xunta de Galicia Centro Singular de Investigacion de Galicia accreditation 2016–2019.CICECO – Aveiro Institute of Materials, POCI-01-0145-FEDER007679 (UID/CTM/50011/2013), the UE ERDF and the Fundación AECC (IDEAS197VAZQ-Singulares 2014), are acknowledged
DS Minerva
RD 24 abr 2026