RT Dissertation/Thesis
T1 Liquid biopsy and precision medicine: Characterization of circulating biomarkers in patients with advanced lung cancer
A1 Mondelo Macía, Patricia
K1 Liquid biopsy
K1 lung cancer
K1 precision medicine
AB The study of liquid biopsy, together with the application of new targetedtherapies, has revolutionized the oncology field. However more research is required to effectively apply thesetechniques into the clinical routine. Although lung cancer is currently one of the tumours in which molecularoncology has more impact, this tumour remains the leading cause of cancer related deaths worldwide, being thedevelopment of tools to guide the therapy selection and monitoring key points to improve this tumour survival rates.With the present thesis we investigated the value of different blood biomarkers for improving the management ofadvanced lung cancer patients through the analysis of circulating free DNA (cfDNA), circulating tumour cells(CTCs), and circulating proteins. We established and validated new protocols to characterize clinically relevantalterations in CTCs and ctDNA and demonstrated the potential of cfDNA monitoring as a prognostic and predictivetool in the context of both NSCLC and SCLC. Of note, we also identified a proteomic signature with value to predictimmunotherapy response in patients with NSCLC. Overall, our results improve the knowledge and applicability ofliquid biopsy analyses in patients with advanced lung cancer and help to advance in precision medicine.
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30919
UL http://hdl.handle.net/10347/30919
LA eng
DS Minerva
RD 24 abr 2026