RT Journal Article
T1 Biomimetic Cell Membrane-Coated Scaffolds for Enhanced Tissue Regeneration
A1 Álvarez Lorenzo, Carmen
A1 Ramírez Romero, Alejandro
A1 Peixoto, Diana
A1 Vivero López, María
A1 Rodríguez-Moldes Rey, María Isabel
A1 Concheiro Nine, Ángel Joaquín
K1 Bioinspired zwitterionization
K1 Bone regeneration
K1 Cell membrane coating
K1 Glycosylation
K1 Regenerative medicine
K1 Scaffold
K1 Wound healing
AB Cell membranes are emerging as valuable models for regulating scaffold-cell interactions in tissue engineering. Their unique structure and function provide an ideal template for creating biomimetic surfaces that support cell adhesion, proliferation, and differentiation. This has led to the development of cell membrane-coated scaffolds (CMCSs), a new class of biomaterials designed to mimic native cellular interfaces and improve therapeutic outcomes. This review begins with an overview of cell–extracellular matrix (ECM) interactions, highlighting their key roles in tissue remodeling and healing. It then introduces ECM-inspired coatings before focusing on CMCSs. A detailed analysis of scaffolds coated with specific membrane components or entire cell membranes is presented, with applications in skin and wound healing, bone regeneration, neural repair, and vascular grafts. Techniques for membrane extraction, surface functionalization, and preservation of membrane integrity and orientation are analyzed. CMCSs demonstrate advantages over traditional scaffolds, including improved homotypic cell attraction, immune modulation, and resistance to non-specific protein and bacterial adhesion. However, several challenges persist, such as standardizing membrane isolation methods, optimizing coating density, and evaluating the stability and reproducibility of coatings, especially when using hybrid membranes from multiple cell types. Overcoming these barriers could significantly advance scaffold technologies for regenerative medicine.
PB Wiley
SN 0935-9648
YR 2025
FD 2025-07-16
LK https://hdl.handle.net/10347/43620
UL https://hdl.handle.net/10347/43620
LA eng
NO References  Alvarez-Lorenzo, C., Ramirez-Romero, A., Peixoto, D., Vivero-Lopez, M., Rodríguez-Moldes, I., & Concheiro, A. (2025). Biomimetic Cell Membrane-Coated Scaffolds for Enhanced Tissue Regeneration. Advanced Materials, 37(40), 2507084. 10.1002/adma.202507084
NO The work was supported by Spain Ministerio de Ciencia, Innovación y Uni-versidades MICIU/AEI/ 10.13039/501100011033 [PID2023-150422OB-I00], ERDF A way of making Europe, cofunded by the European Union,and Xunta de Galicia [ED431C 2024/09].
DS Minerva
RD 3 may 2026