RT Journal Article
T1 Green CO2 technology for the preparation of aerogel dry powder loaded with beclomethasone dipropionate
A1 Duong, Thoa
A1 López Iglesias, Clara
A1 Bianchera, Annalisa
A1 Vivero López, María
A1 Ardao Palacios, Inés
A1 Bettini, Ruggero
A1 Álvarez Lorenzo, Carmen
A1 García González, Carlos A.
K1 Green technology
K1 Supercritical CO2
K1 Dry powder inhalers
K1 Beclomethasone dipropionate
K1 Drug-loaded aerogel
AB Dry powder inhalers (DPIs) have gained increasing clinical acceptance in the local treatment of lung diseases due to their ability to meet the evolving needs of patients while avoiding environmental concerns. However, some formulations for DPIs still encounter performance limitations in terms of aerodynamic properties and achievement of therapeutic doses. Innovative aerogel powder formulations for DPIs processed using combined supercritical CO2 (scCO2)-based technologies can overcome these limitations, especially in the case of poorly water-soluble drugs. The loading of hydrophobic drugs into aerogels can be optimized through a thorough understanding of the physicochemical properties of the formulation and the scCO2 processing conditions. In this study, drug-loaded alginate aerogel particles were prepared by combining gelation-emulsification techniques and scCO2-based technologies. Beclomethasone dipropionate (BDP), a hydrophobic corticosteroid, was incorporated into the aerogel matrix by scCO2 impregnation. The influence of contact time, initial amount of drug, and use of co-solvents on the efficiency of scCO2 impregnation were studied. The kinetics of the BDP adsorption process was modelled to elucidate the time required for the drug to attain equilibrium concentration under specific operating conditions. Nitrogen adsorption-desorption and helium pycnometry revealed particles with large surface area (>200 m2/g) and porosity (ca. 90%). The resulting aerogels had excellent aerodynamic properties at relevant BDP doses, as confirmed by in vitro lung deposition tests. Ex vivo permeability tests with porcine lung tissues evidenced that BDP released from the inhaled formulation could penetrate the bronchial tissue
PB Elsevier
SN 2212-9820
YR 2024
FD 2024
LK http://hdl.handle.net/10347/33784
UL http://hdl.handle.net/10347/33784
LA eng
NO Journal of CO2 Utilization, Volume 81, 2024, 102722
NO Work supported by MICINN [PID2020–120010RB-I00/AEI/10.13039/501100011033], Agencia Estatal de Investigación [AEI] and FEDER funds. This publication is based upon work from ECO-AERoGELS COST Innovation Grant (ref. IG18125) supported by the European Commission. Th. D. acknowledges the support of Diputación Provincial de A Coruña for research in health science 2022–2023 (BINV-CS/2022) and of AERoGELS COST Action (ref. CA18125) for a Short Term Scientific Missions (STSM) grant to undergo the in vitro aerodynamic drug deposition tests of aerogels in the University of Parma (Italy). Clara López-Iglesias acknowledges Xunta de Galicia for her Postdoctoral contract (ED481B 2021/008). The authors would like to thank Ezequiel Vázquez Fernández, Carlos Illanes-Bordomás and Miguel Pereira-Silva (University of Santiago de Compostela, Spain) for their valuable support and technical help with Raman spectroscopy, analysis of SEM images and dialysis method in in vitro drug release studies, respectively
DS Minerva
RD 27 abr 2026