RT Journal Article
T1 Methyl derivatives of tetracyclic psoralen analogues: antiproliferative activity and interaction with DNA
A1 Dalla Via, Lisa
A1 Uriarte Villares, Eugenio
A1 Santana Penín, María Lourdes
A1 Marciani Magno, Sebastiano
A1 Gia, Ornella
K1 Tetracyclic psoralen analogues
K1 Antiproliferative activity
K1 DNA interaction
AB A number of new tetracyclic psoralen derivatives were studied. The fourth ring is constituted bycyclopentane (4, 7 and 9), cyclohexane (11, 15 and 18) or benzene (12, 16 and 20) fused to either4',5' or 3,4 photoreactive double bond of tricyclic furocoumarin moiety. Thephotoantiproliferative activity of all compounds, tested on two human tumor cell lines (HeLa andHL-60), appeared from 8 to 22 times higher than that of the well-known photochemotherapeuticdrug 8-methoxypsoralen (8-MOP) in HeLa, slightly higher in HL-60. Interestingly, theevaluation of skin phototoxicity on guinea pigs evidenced a decrease in erythema induction forall compounds with respect to the drug. As regards the molecular mechanism of action, theability to photoadd to DNA is demonstrated by isolation and characterization of the photoadductsand by the ability to give rise to interstrand cross-links for the difunctional derivatives
PB Arkat USA Inc
SN 1551-7004
YR 2004
FD 2004
LK http://hdl.handle.net/10347/23462
UL http://hdl.handle.net/10347/23462
LA eng
NO Dalla Via, Lisa, Uriarte, Eugenio, Santana, Lourdes, Marciani Magno, Sebastiano, Gia, Ornella. Methyl derivatives of tetracyclic psoralen analogues: antiproliferative activity and interaction with DNA . Arkivoc 2004, p. 131-146
DS Minerva
RD 24 abr 2026