RT Journal Article
T1 Redefining dilute and shoot: The evolution of the technique and its application in the analysis of foods and biological matrices by liquid chromatography mass spectrometry
A1 Greer, Brett
A1 Chevallier, Olivier P.
A1 Quinn, Brian
A1 Botana López, Luis Miguel
A1 Elliot, Christopher T.
K1 Dilute-and-shoot
K1 Liquid chromatography
K1 Mass spectrometry
K1 Sample preparation
K1 Food analysis
K1 Bioanalysis
K1 Mycotoxin
K1 Multi-class
AB With laboratories seeking to expand analytical capabilities and create multi-class, multi-analyte methods, there has been a shift toward generic sample clean-up techniques such as “dilute-and-shoot”. Advantages of this methodology include its simplicity, minimal analyte losses, high sample throughput and number of analyte classes included. The evolution of dilute-and-shoot has permitted its use across a variety of matrices including food and biological and in various scientific fields such as food, forensics and environmental. The versatility of the technique permits the expansion of current fields of research without the usual laborious method development. There can be issues with matrix effects and robust quantitation as analyte number increases. This review provides an overview of the technique combined with liquid chromatography mass spectrometry, highlighting its power in facilitating multi-class analysis. Coupled with increases in instrument performance there is potential to employ this methodology in expanding analytical capabilities in many areas of life science research
PB Elsevier
SN 0165-9936
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26229
UL http://hdl.handle.net/10347/26229
LA eng
NO Trends in Analytical Chemistry, 141 (2021), 116284
NO This work was supported by Agritox, a project funded by the Interreg Atlantic Area Programme through the European Regional Development Fund [EAPA 998/2018] and by the InvestNI funded Agri-Food Competence Centre project Food Fortress [11-12-17-001]
DS Minerva
RD 8 jun 2026