RT Journal Article
T1 Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways
A1 Rodrigues Amorim, Daniela
A1 Rivera Baltanás, Tania
A1 Vallejo Curto, María del Carmen
A1 Rodríguez Jamardo, Cynthia
A1 Heras, Elena de las
A1 Barreiro Villar, Carolina
A1 Blanco Formoso, María
A1 Fernández Palleiro, Patricia
A1 Álvarez Ariza, María
A1 López García, Marta
A1 García Caballero, Alejandro Alberto
A1 Olivares Díez, José Manuel
A1 Spuch, Carlos
K1 Schizophrenia
K1 Proteomics
K1 Liquid chromatography–tandem mass spectrometry
K1 Rab3 GTPaseactivating protein catalytic subunit
K1 Glia maturation factor beta
K1 Brain-derived neurotrophic factor
AB Schizophrenia is a severe and disabling psychiatric disorder with a complex andmultifactorial etiology. The lack of consensus regarding the multifaceted dysfunction of thisailment has increased the need to explore new research lines. This research makes useof proteomics data to discover possible analytes associated with psychoneuroimmunesignaling pathways in schizophrenia. Thus, we analyze plasma of 45 patients [10 patientswith first-episode schizophrenia (FES) and 35 patients with chronic schizophrenia] and43 healthy subjects by label-free liquid chromatography–tandem mass spectrometry. Theanalysis revealed a significant reduction in the levels of glia maturation factor beta (GMF-β), the brain-derived neurotrophic factor (BDNF), and the 115-kDa isoform of the Rab3GTPase-activating protein catalytic subunit (RAB3GAP1) in patients with schizophreniaas compared to healthy volunteers. In conclusion, GMF-β, BDNF, and 115-kDa isoform ofRAB3GAP1 showed significantly reduced levels in plasma of patients with schizophrenia,thus making them potential biomarkers in schizophrenia.
PB Frontiers Media
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21228
UL http://hdl.handle.net/10347/21228
LA eng
NO Rodrigues-Amorim D, Rivera-Baltanás T, Vallejo-Curto MdC, Rodriguez-Jamardo C, de las Heras E, Barreiro-Villar C, Blanco-Formoso M, Fernández-Palleiro P, Álvarez-Ariza M, López M, García-Caballero A, Olivares JM and Spuch C (2019) Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways. Front. Psychiatry 10:885. doi: 10.3389/fpsyt.2019.00885
NO This work was financially backed by the Foundation for Science and Technology (FCT, Fundação para a Ciência e Tecnologia) within the framework of grant SFRH/BD/135623/2018 awarded to Daniela Rodrigues- Amorim, and another grant of Fundación Tatiana Pérez de Guzmanel Bueno provided to Carlos Spuch. Our research was further supported by the Carlos III Health Institute (ISCIII, Instituto Carlos III) through grant P16/00405and co-funding awarded by the Spanish Foundation of Rare Diseases (FEDER, Fundación Española de Enfermedades Raras) to José Manuel Olivares
DS Minerva
RD 24 abr 2026