RT Journal Article
T1 Genomic degradation of a young Y chromosome in Drosophila miranda
A1 Bachtrog, Doris
A1 Hom, Emily
A1 Wong, Karen M.
A1 Maside Rodríguez, Xulio Manuel
A1 Jong, Pieter de
K1 Bacterial Artificial Chromosome
K1 Bacterial Artificial Chromosome Clone
K1 Bacterial Artificial Chromosome Library
K1 Transposable Element Insertion
K1 Transposable Element Abundance
AB Background: Y chromosomes are derived from ordinary autosomes and degenerate because of a lack of recombination. Well-studied Y chromosomes only have few of their original genes left and contain little information about their evolutionary origin. Here, we take advantage of the recently formed neo-Y chromosome of Drosophila miranda to study the processes involved in Y degeneration on a genomic scale.Results: We obtained sequence information from 14 homologous bacterial artificial chromosome (BAC) clones from the neo-X and neo-Y chromosome of D. miranda, encompassing over 2.5 Mb of neo-sex-linked DNA. A large fraction of neo-Y DNA is composed of repetitive and transposable-element-derived DNA (20% of total DNA) relative to their homologous neo-X linked regions (1%). The overlapping regions of the neo-sex linked BAC clones contain 118 gene pairs, half of which are pseudogenized on the neo-Y. Pseudogenes evolve significantly faster on the neo-Y than functional genes, and both functional and non-functional genes show higher rates of protein evolution on the neo-Y relative to their neo-X homologs. No heterogeneity in levels of degeneration was detected among the regions investigated. Functional genes on the neo-Y are under stronger evolutionary constraint on the neo-X, but genes were found to degenerate randomly on the neo-Y with regards to their function or sex-biased expression patterns.Conclusion:Patterns of genome evolution in D. miranda demonstrate that degeneration of a recently formed Y chromosome can proceed very rapidly, by both an accumulation of repetitive DNA and degeneration of protein-coding genes. Our data support a random model of Y inactivation, with little heterogeneity in degeneration among genomic regions, or between functional classes of genes or genes with sex-biased expression patterns
PB BMC
SN 1474-760X
YR 2008
FD 2008
LK http://hdl.handle.net/10347/24265
UL http://hdl.handle.net/10347/24265
LA eng
NO Bachtrog, D., Hom, E., Wong, K.M. et al. Genomic degradation of a young Y chromosome in Drosophila miranda. Genome Biol 9, R30 (2008). https://doi.org/10.1186/gb-2008-9-2-r30
NO This research is funded by NIH Grant GM076007 and a Sloan Fellowship to DB. BAC library construction was funded by a Wellcome Trust grant to P Keightley and B Charlesworth. P Andolfatto provided funds for the sequence of two BAC clones
DS Minerva
RD 24 abr 2026