RT Journal Article
T1 Do polygenic risk and stressful life events predict pharmacological treatment response in obsessive compulsive disorder? A gene–environment interaction approach
A1 Alemany Navarro, María
A1 Costas Costas, Javier
A1 Real, Eva
A1 Segalás, Cinto
A1 Bertolín, Sara
A1 Domenech, Laura
A1 Rabionet, Raquel
A1 Carracedo Álvarez, Ángel
A1 Menchón, José M.
A1 Pino Alonso, María del
AB The rate of response to pharmacological treatment in Obsessive-compulsive disorder (OCD) oscillates between 40 and70%. Genetic and environmental factors have been associated with treatment response in OCD. This study analyzes thepredictive ability of a polygenic risk score (PRS) built from OCD-risk variants, for treatment response in OCD, and themodulation role of stressful life events (SLEs) at the onset of the disorder. PRSs were calculated for a sample of 103patients. Yale–Brown Obsessive Compulsive Scale (YBOCS) scores were obtained before and after a 12-week treatment.Regression analyses were performed to analyze the influence of the PRS and SLEs at onset on treatment response. PRSdid not predict treatment response. The best predictive model for post-treatment YBOCS (post YBOCS) included basalYBOCS and age. PRS appeared as a predictor for basal and post YBOCS. SLEs at onset were not a predictor for treatmentresponse when included in the regression model. No evidence for PRS predictive ability for treatment response wasfound. The best predictor for treatment response was age, agreeing with previous literature specific for SRI treatment.Suggestions are made on the possible role of neuroplasticity as a mediator on this association. PRS significantlypredicted OCD severity independent on pharmacological treatment. SLE at onset modulation role was not evidenced.Further research is needed to elucidate the genetic and environmental bases of treatment response in OCD.
PB Springer Nature
YR 2019
FD 2019-02-04
LK http://hdl.handle.net/10347/21128
UL http://hdl.handle.net/10347/21128
LA eng
NO Alemany-Navarro, M., Costas, J., Real, E. et al. Do polygenic risk and stressful life events predict pharmacological treatment response in obsessive compulsive disorder? A gene–environment interaction approach. Transl Psychiatry 9, 70 (2019). https://doi.org/10.1038/s41398-019-0410-0
NO This study was supported in part by the Carlos III Health Institute (PI13/01958,PI13/00918, PI14/00413 and PI16/00950); FEDER funds (‘A way to build Europe’)and by the Agency of University and Research Funding Management of theCatalan Government (2014SGR1672). We also acknowledge support of theSpanish Ministry of Economy and Competitiveness, ‘Centro de ExcelenciaSevero Ochoa 2017-2021’, SEV-2016-0571 and of the Spanish MINECOSAF2013-49108-R Plan Estatal. M.A. was supported by the Secretariat forUniversities and Research of the Ministry of Business and Knowledge of theGovernment of Catalonia. Grant co-funded by the European Social Fund (ESF)“ESF, Investing in your future” (2017 FI_B 00327). E.R. was supported by a JuanRodés contract (JR14/00038)
DS Minerva
RD 28 abr 2026