RT Journal Article
T1 Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras
A1 Mosquera Mosquera, Jesús
A1 Rodríguez Villar, Jéssica
A1 Vázquez Sentís, Marco Eugenio
A1 Mascareñas Cid, José Luis
K1 DNA recognition
K1 Molecular recognition
K1 Oligonucleotides
K1 Peptides
K1 Supramolecular chemistry
AB We report the construction of conjugates between three variants of the helix 3 region of a Q50K engrailed homeodomain and bisbenzamidine minor-groove DNA binders. The hybrid featuring the sequence of the native protein failed to bind to DNA; however, modifications that increased the α-helical folding propensity of the peptide allowed specific DNA binding by a bipartite (major/minor groove) interaction
PB WILEY-VCH Verlag GmbH
SN 1439-7633
YR 2014
FD 2014-04-24
LK http://hdl.handle.net/10347/11967
UL http://hdl.handle.net/10347/11967
LA eng
NO Mosquera, J., Rodríguez, J., Vázquez, M. E. and Mascareñas, J. L. (2014), Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras. ChemBioChem, 15: 1092–1095. doi: 10.1002/cbic.201400079
NO Ministerio de Economía y Competitividad. Grant Numbers: SAF2010-20822-C02, CTQ2012-31341Consolider Ingenio. Grant Number: 2010 CSD2007-00006Xunta de Galicia. Grant Number: GRC2013/14European Regional Development FundEuropean Research Council. Grant Number: Na 340055Ministerio de Ciencia e InnovaciónFundación Gil Dávila
DS Minerva
RD 28 abr 2026