RT Journal Article
T1 Hyperthermia in human ischemic and hemorrhagic stroke: similar outcome, different mechanisms
A1 Campos Pérez, Francisco
A1 Sobrino Moreiras, Tomás
A1 Vieites Prado, Alba
A1 Pérez Mato, María
A1 Rodríguez Yáñez, Manuel
A1 Blanco González, Miguel
A1 Castillo Sánchez, José Antonio
AB Hyperthermia is a predictor of poor outcome in ischemic (IS) and intracerebral hemorrhagic (ICH) stroke. Our aim was to study the plausible mechanisms involved in the poor outcome associated to hyperthermia in stroke. We conducted a case-control study including patients with IS (n = 100) and ICH (n = 100) within the first 12 hours from symptom onset. Specifically, IS and ICH patients were consecutively included into 2 subgroups, according to the highest body temperature within the first 24 hours: Tmax <37.5°C and Tmax ≥37.5°C, up to reach 50 patients per subgroup of temperature for both IS and ICH patients. Body temperature was determined at admission and every 4 hours during the first 48 hours. Main outcome variable was poor functional outcome (modified Rankin scale score >2) at 3 months. Serum levels of glutamate and active MMP-9 were measured at admission. Our results showed that Tmax ≥37.5°C within the first 24 hours was independently associated with poor outcome in both IS (OR, 12.43; 95% CI, 3.73–41.48; p<0.0001) and ICH (OR, 4.29; 95% CI, 1.32–13.91; p = 0.015) after adjusting for variables with a proven biological relevance for outcome. However, when molecular markers levels were included in the logistic regression model, we observed that glutamate (OR, 1.01; 95% CI, 1.00–1.02; p = 0.001) and infarct volume (OR, 1.06; 95% CI, 1.01–1.10; p = 0.015) were the only variables independently associated to poor outcome in IS, and active MMP-9 (OR, 1.04; 95% CI, 1.00–1.08; p = 0.002) and National Institute of Health Stroke Scale (NIHSS) at admission (OR, 1.29; 95% CI, 1.13–1.49; p<0.0001) in ICH. In conclusion, these results suggest that although the outcome associated to hyperthermia is similar in human IS and ICH, the underlying mechanisms may be different.
PB PLOS
YR 2013
FD 2013
LK http://hdl.handle.net/10347/22166
UL http://hdl.handle.net/10347/22166
LA eng
NO Campos F, Sobrino T, Vieites-Prado A, Pérez-Mato M, Rodríguez-Yáñez M, Blanco M, et al. (2013) Hyperthermia in Human Ischemic and Hemorrhagic Stroke: Similar Outcome, Different Mechanisms. PLoS ONE 8(11): e78429. https://doi.org/10.1371/journal.pone.0078429
NO This project has been partially supported by grants from the Spanish Ministry of Economy and Competitiveness SAF2011-30517, Xunta de Galicia (Consellería Economía Industria: 10PXIB918282PR; and Consellería Educación: CN2011/010), Instituto de Salud Carlos III (PI11/00909 and CP12/03121), Spanish Research Network on Cerebrovascular Diseases RETICS-INVICTUS (RD12/0014), COST Action BM1001 “Brain Extracellular Matrix in Health and Disease”, Fundación Mútua Madrileña and by the European Union program FEDER. Furthermore, T. Sobrino is recipient of a research contract from Miguel Servet Program of Instituto de Salud Carlos III
DS Minerva
RD 28 abr 2026