RT Journal Article
T1 Expansion of a CD26low Effector TH Subset and Reduction in Circulating Levels of sCD26 in Stable Allergic Asthma in Adults
A1 Nieto Fontarigo, Juan José
A1 González Barcala, Francisco Javier
A1 San-José, M. E.
A1 Cruz, M. J.
A1 Linares, T.
A1 Soto-Mera, M. T.
A1 Valdés Cuadrado, Luis
A1 García-González, M. A.
A1 Andrade-Bulos, L. J.
A1 Arias Crespo, María del Pilar
A1 Nogueira Álvarez, Montserrat
A1 Salgado Castro, Francisco Javier
K1 Asthma biomarkers
K1 CD25
K1 CD26
K1 DPP4
K1 Helper T cells
K1 Lymphocytes
AB Background: The pathogenesis of asthma is dependent on the balance between regulatory and effector T cells, which display differential expression of CD25 and CD26. Therefore, alteration of circulating levels of sCD25 and sCD26 during allergic asthma could be conditioned by changes in leukocyte phenotype.Objectives: To analyze expression of CD25 and CD26 on T lymphocytes and their soluble derivatives (sCD25, sCD26) during stable phases of moderate-severe allergic asthma.Methods: Cross-sectional study with 2 adult cohorts of allergic asthmatics. Clinical, anthropometric, pulmonary, hematological, and biochemical parameters were measured. Phenotyping was performed with flow cytometry in both circulating and cultured leukocytes. Dipeptidyl peptidase 4 (DPP4) activity was assayed in culture supernatants.Results: In vitro studies revealed upregulation of CD26 on human T lymphocytes upon activation, especially under TH17-favoring conditions, and a correlation with soluble DPP4 activity (rs=0.641; P<.001). CD26 expression on lymphocytes was higher in asthmatics, while serum sCD26 was lower in women and patients. The latter finding could be associated with an expanded CD25low/CD26low/CD127low subset of effector CD4+ T cells in allergic asthma, with no changes in Treg percentages. However, women showed an increased Teff/Treg ratio, which could explain their greater susceptibility to asthma.Conclusions: Allergic asthma causes an increment in CD25lowCD26low helper T cells detected in stable stages. These changes are mirrored in serum and should be considered in the light of the downmodulating role of CD26 in major chemokines related to the pathogenesis of asthma such as CCL11 (eotaxin), CCL5 (RANTES), and CXCL12a (SDF-1α).
PB Esmon
SN 1018‑9068
YR 2018
FD 2018-04-16
LK https://hdl.handle.net/10347/42122
UL https://hdl.handle.net/10347/42122
LA eng
NO J Investig Allergol Clin Immunol 2018; Vol 28(2) : 113-125
DS Minerva
RD 24 abr 2026