RT Journal Article
T1 Astrocyte Clocks and Glucose Homeostasis
A1 Barca Mayo, Olga
A1 López Pérez, Miguel A.
K1 Astrocytes
K1 Circadian clock
K1 Metabolism
K1 Diabetes
K1 Glucose homeostasis
AB The endogenous timekeeping system evolved to anticipate the time of the day through the 24 hours cycle of the Earth’s rotation. In mammals, the circadian clock governs rhythmic physiological and behavioral processes, including the daily oscillation in glucose metabolism, food intake, energy expenditure, and whole-body insulin sensitivity. The results from a series of studies have demonstrated that environmental or genetic alterations of the circadian cycle in humans and rodents are strongly associated with metabolic diseases such as obesity and type 2 diabetes. Emerging evidence suggests that astrocyte clocks have a crucial role in regulating molecular, physiological, and behavioral circadian rhythms such as glucose metabolism and insulin sensitivity. Given the concurrent high prevalence of type 2 diabetes and circadian disruption, understanding the mechanisms underlying glucose homeostasis regulation by the circadian clock and its dysregulation may improve glycemic control. In this review, we summarize the current knowledge on the tight interconnection between the timekeeping system, glucose homeostasis, and insulin sensitivity. We focus specifically on the involvement of astrocyte clocks, at the organism, cellular, and molecular levels, in the regulation of glucose metabolism
PB Frontiers Media
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26763
UL http://hdl.handle.net/10347/26763
LA eng
NO Front. Endocrinol. 2021, 12:662017. https://doi.org/10.3389/fendo.2021.662017
NO OB-M is supported with a Ramón y Cajal award (RYC2018‐026293‐I.) from the Ministerio de Ciencia, Innovación y Universidades of Spain; by Spanish Agencia Estatal de Investigación (PID2019-109556RB-I00) and the Xunta de Galicia-Consellería de Cultura, Educación e Ordenación Universitaria (ED431F 2020/009)
DS Minerva
RD 28 abr 2026