RT Journal Article
T1 Sleep quality and risk of recurrent aphthous ulcers: A Spanish cohort study
A1 Tohidinik, Hamid Reza
A1 Rodríguez Fernández, María de la Almudena
A1 Regueira Méndez, Carlos Manuel Pastor
A1 Takkouche, Bahi
K1 Adolescents
K1 Aphthous stomatitis
K1 Hypersomnia
K1 Insomnia
K1 Oral mucosa
K1 Sleep
AB Objective: Recurrent aphthous stomatitis (RAS) is a condition that affects 20% of the world population and is characterized by painful ulcers in the oral mucosa. So far, the epidemiology and risk factors of RAS have been infrequently studied. Our objective was to determine whether sleep-related factors are related to the occurrence of RAS in the first prospective study carried out on this topic.Methods: A cohort of 11210 Spanish students, 13–17 years old, was followed up for one year. Sleep disorders were assessed at baseline using a standard validated questionnaire.Results: We detected 2655 new cases of RAS with a total of 287,262 person-week of follow-up. Subjects with high (4th quartile) Insomnia Index showed an incidence rate ratio (IRR) of RAS of 1.29 (95% confidence interval (CI) 1.15–1.45), while subjects with high Hypersomnia Index presented an IRR of 1.42 (95% CI 1.26–1.61). A high score of sleep-related phenomena was also associated with an increased IRR: 1.53 (95% CI 1.37–1.69). Adolescents with high level of sleep satisfaction were at lower risk of RAS: 0.88 (95% CI 0.77–1.01).Conclusion: These findings suggest that sleep disorders are moderately associated with RAS in adolescents
PB Wiley
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26621
UL http://hdl.handle.net/10347/26621
LA eng
NO Tohidinik, H. R., Rodríguez, A., Regueira-Méndez, C., & Takkouche, B. (2021). Sleep quality and risk of recurrent aphthous ulcers: A Spanish cohort study. Oral Diseases, 00, 1– 9. https://doi.org/10.1111/odi.13955
NO This work was funded by the Regional Ministry of Education, Universities and Vocational Training (Consellería de Educación, Universidades y Formación Profesional) [Grant number ED431C 2018/20], Santiago de Compostela, Spain
DS Minerva
RD 24 abr 2026