RT Journal Article
T1 Comparison of Central Corneal Thickness measured by Standard Ultrasound Pachymetry, Corneal Topography, Tono-Pachymetry and Anterior Segment Optical Coherence Tomography
A1 González Pérez, Javier
A1 Queiruga Piñeiro, Juan
A1 Sánchez García, Ángel
A1 González Méijome, José Manuel
K1 Central corneal thickness
K1 Scheimpflug camera
K1 Anterior segment optical coherence tomography
K1 Interchangeability
K1 Non-contact tono-pachymetry
K1 Ultrasound pachymetry
AB Purpose: To compare central corneal thickness (CCT) measured by standard ultrasound pachymetry (USP), and three non-contact devices in healthy eyes.Methods: A cross-sectional study of CCT measurement in 52 eyes of 52 healthy volunteers was done by a single examiner at Ocular Surface and Contact Lens Laboratory. Three consecutive measurements were done by standard USP, non-contact tono-pachymeter, Pentacam corneal topographer, and Anterior Segment Optical Coherence Tomography (AS-OCT). The mean values were used for assessment. The results were compared using multivariate ANOVA, linear regression, and Pearson correlation. Agreement among the devices was analyzed using mean differences and Bland-Altman analysis with 95% limits of agreement (LoA). Finally, reliability was analyzed using intraclass correlation coefficient (ICC).Results: Mean CCT by ultrasound pachymeter, tono-pachymeter, corneal topographer and AS-OCT were 558.9 ± 31.2 µm, 525.8 ± 43.1 µm, 550.4 ± 30.5 µm, and 545.9 ± 30.5 µm respectively. There was a significant positive correlation between AS-OCT and USP (Pearson correlation = 0.957, p < 0.001), corneal topography and USP (Pearson correlation = 0.965, p < 0.001), and corneal topography and AS-OCT (Pearson correlation = 0.965, p < 0.001). There was a lower correlation between CT-1P tono-pachymeter and the other three modalities. Intraclass correlation coefficients show an excellent reliability between pairs except for CT-1P against the other three instruments that were found moderate.Conclusions: CT-1P tono-pachymeter underestimates CCT measurements compared to Scheimpflug system, AS-OCT device, and USP. Mean CCT among USP, Pentacam and AS-OCT were comparable and had significant linear correlations. In clinical practice, these three modalities could be interchangeable in healthy patients.
PB Taylor and Francis Group
SN 0271-3683
YR 2018
FD 2018
LK http://hdl.handle.net/10347/32634
UL http://hdl.handle.net/10347/32634
LA eng
NO González-Pérez J, Queiruga Piñeiro J, Sánchez García Á, González Méijome JM. Comparison of Central Corneal Thickness Measured by Standard Ultrasound Pachymetry, Corneal Topography, Tono-Pachymetry and Anterior Segment Optical Coherence Tomography. Curr Eye Res. 2018 Jul;43(7):866-872. doi: 10.1080/02713683.2018.1461910. Epub 2018 Apr 13.
NO This is an Accepted Manuscript version of the following article, accepted for publication in Current Eye Research. [González-Pérez J, Queiruga Piñeiro J, Sánchez García Á, González Méijome JM. Comparison of Central Corneal Thickness Measured by Standard Ultrasound Pachymetry, Corneal Topography, Tono-Pachymetry and Anterior Segment Optical Coherence Tomography. Curr Eye Res. 2018 Jul;43(7):866-872]. It is deposited under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
DS Minerva
RD 30 abr 2026