RT Journal Article
T1 Tuning the properties of penetrating peptides by oxime conjugation
A1 Pazo Pascual, Marta
A1 Fernández Caro, Héctor
A1 Priegue Caamaño, Juan Manuel
A1 Lostalé Seijo, Irene
A1 Montenegro García, Javier
K1 Peptide chemistry
K1 Penetrating peptides
K1 Supramolecular chemistry
K1 Membrane transport
K1 Solid-phase peptide synthesis
AB We here describe the application of oxime bond formation between a peptide scaffold and different aldehydes to modify the transporting capabilities of penetrating peptides. We show that bonds such as oximes offer a great synthetic advantage for the modification of the properties of model penetrating peptides. We believe that this approach will allow the development of improved intracellular delivery vehicles
PB Georg Thieme Verlag
SN 0936-5214
YR 2017
FD 2017-01-25
LK http://hdl.handle.net/10347/15141
UL http://hdl.handle.net/10347/15141
LA eng
NO Montenegro, Javier, Pazo, Marta, Fernández-Caro, Héctor, Priegue, Juan and Lostalé-Seijo, Irene, 2017, Tuning the Properties of Penetrating Peptides by Oxime Conjugation. Synlett. 2017. DOI 10.1055/s-0036-1588689. Thieme Publishing Group
NO This work was supported by the Spanish Ministry of Economy and Competitivity (MINECO) [CTQ2014-59646-R], the Xunta de Galicia (ED431G/09) and the ERDF. J.P. received an F.P.I. fellowship from MINECO. J.M. received a Ramon y Cajal (RYC-2013-13784) and an ERC Starting Investigator Grant (DYNAP-677786)
DS Minerva
RD 24 abr 2026