RT Journal Article
T1 Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility
A1 Vargas Osorio, Zulema
A1 Luzardo Álvarez, Asteria María
A1 Piñeiro Redondo, Yolanda
A1 Vázquez Vázquez, Carlos
A1 Gómez Amoza, José Luis
A1 Blanco Méndez, José
A1 Otero Espinar, Francisco Javier
A1 Rivas Rey, José
AB The development of scaffolds with suitable physicochemical and mechanical properties allowing for thestructural regeneration of injured bone and recovery of the natural biological functionality is still a challenge in the tissueengineering field. Nanostructured materials with added theranostic abilities, together with an interconnected hierarchy of pores,offer the possibility to provide a new generation of bone implants. In this work, scaffolds with highly porous and resistant threedimensional structures have been successfully developed by homogeneously embedding mesoporous silica nanostructures in abioactive matrix of chitosan/κ-carrageenan. Moreover, magnetite (Fe3O4) nanoparticles were also added to the mesoporousscaffold to include additional magnetic functionalities for diagnostic or therapeutic actions. The complete physicochemicalcharacterization shows mesoporous materials with a wide range of interconnected pores, remarkable surface roughness, andlarge effective surface area, suitable for cell adhesion. In accordance to these properties, a simvastatin loading and release assayshowed high loading capacities and sustained release over a long period of time. Together with a suitable resistance againstdegradation and biocompatible performance assessed by cell viability assays, these scaffolds show interesting features fordelivering drugs with activity in bone regeneration processes.
PB American Chemical Society
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21348
UL http://hdl.handle.net/10347/21348
LA eng
NO Vargas-Osorio, Z., Luzardo-Álvarez, A., Piñeiro, Y., Vázquez-Vázquez, C., Gómez-Amoza, J.L., Blanco-Méndez, J., Otero Espinar, F.J., Rivas, J. (2019) Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility. "ACS Omega", 4 (3), 5496-5508
NO This work was supported by the European Commission (PANA project, Call H2020-NMP-2015-two-stage, grant 686009); and the Xunta de Galicia (GPC2017/015), and partially supported by the Consellería de Educacion Program ́ for the Development of Strategic Grouping in Materials AEMAT at the University of Santiago de Compostela under grant no. ED431E2018/08, Xunta de Galicia and Program for the Consolidation of Research Units of Competitive Reference GRC2017, grant no. ED431C 2017/22
DS Minerva
RD 29 abr 2026