RT Journal Article
T1 Surface-modified iron oxide nanoprobes in biomedical scaffolds
A1 González Gómez, Manuel Antonio
A1 Arnosa Prieto, Ángela
A1 García Acevedo, Pelayo
A1 Díaz Rodríguez, Patricia
A1 Castro Alves, Lisandra de
A1 Piñeiro Redondo, Yolanda
A1 Rivas Rey, José
AB Magnetic (PU) scaffolds incorporating superparamagnetic iron oxide nanoparticles (SPIONs) offer a promising platform for localized cancer therapy. By enhancing the functional performance of these scaffolds through surface modification of iron oxide nanoprobes, their biomedical utility—particularly in targeted therapeutic applications—can be significantly improved. In this study, we report the synthesis and characterization of magnetite nanoparticles (Fe3O4 NPs) functionalized with biocompatible coatings—citrate, polyethylene glycol (PEG), oleic acid (OA), and aluminum hydroxide (Al(OH)3)—and their integration into porous PU scaffolds via a salt-leaching/phase-inversion method. Among all tested formulations, SPIONs@Al(OH) demonstrated superior colloidal stability, magnetic responsiveness, and cytocompatibility. When embedded in PU scaffolds, these magnetic nanocomposites exhibited optimal mesoporosity, homogeneous nanoparticle distribution, and efficient magnetic hyperthermia performance under clinically relevant alternating magnetic fields. This work highlights the synergistic potential of material design and surface engineering in developing next-generation implantable platforms for targeted oncological treatment.
PB Royal Society of Chemistry
YR 2025
FD 2025-11-17
LK https://hdl.handle.net/10347/46921
UL https://hdl.handle.net/10347/46921
LA eng
NO González-Gómez, M.A., Arnosa-Prieto, Á., García-Acevedo, P., Díaz-Rodríguez, P., Castro-Alves, L. de, Piñeiro, Y., & Rivas, J. (2025). Surface-modified iron oxide nanoprobes in biomedical scaffolds. Nanoscale Advances, 7(24), 8093–8103. https://doi.org/10.1039/d5na00605h
NO This work was partly supported by the Predoctoral Support Program 2020 and the Postdoctoral Fellowship Grant (ED481B Call 2023) from Xunta de Galicia, Spain. Funding for the CARTsol project (PLEC2022-009217) is partially acknowledged within the framework of the Strategic Research Plan 2021–2023, as part of the Recovery, Transformation, and Resilience Plan, 2022 call by the Ministry of Science and Innovation of Spain. P. García-Acevedo thanks to Axencia Galega de Innovación (Spain) for his Posdoctoral Grant (Axudas de apoio á etapa deformación posdoutoral– IN606B-2024.1).
DS Minerva
RD 9 may 2026