RT Journal Article T1 Self-efficacy and sex influences on the relationship between tobacco dependence and long-term abstinence: a moderated mediation approach A1 López Durán, Ana A1 Martínez Vispo, Carmela A1 Suárez Castro, Daniel A1 Barroso Hurtado, María A1 Míguez Varela, María del Carmen A1 Becoña Iglesias, Elisardo K1 Tobacco dependence K1 Self-efficacy K1 Sex K1 12-months quitting success K1 Cognitive-behavioral intervention AB Tobacco dependence and abstinence self-efficacy are interrelated, and both are relevant variables for quitting smoking. Previous literature suggests that sex may also be a key factor in this relationship. This study aims to examine the relationship between tobacco dependence, self-efficacy and 12-months abstinence, and to explore the role of sex in this relationship. A total sample of 288 adult treatment-seeking daily smokers (Mage = 45.8, SD = 10.63; 62.5% females) was used. Participants were enrolled in a cognitive-behavioral smoking cessation treatment and were followed during a one-year period. We found a negative correlation between baseline tobacco dependence and smoking self-efficacy at the end of the intervention. Mediation analysis showed a significant indirect effect of tobacco dependence on quitting smoking via self-efficacy (B = -0.162, SE = 0.053, 95% BootCI [-0.287, -0.082]). We also found that sex significantly moderated the relationship between baseline tobacco dependence and self-efficacy at the end of the intervention. This result indicates that the indirect effect of tobacco dependence on quitting success through smoking self-efficacy was significant for females (B = -0.239, SE = 0.069, 95% BootCI [-0.402, -0.131]), but not for males. Self-efficacy has key role in the association between tobacco dependence and long-term abstinence, being particularly relevant for females. These findings contribute to understanding the role of tobacco dependence on abstinence, which is a well-known barrier to smoking cessation, and have several clinical implications as focusing on post-treatment self-efficacy in those with higher dependence could be relevant to improving the effectiveness of interventions to quit. PB Springer Nature Link SN 1046-1310 YR 2026 FD 2026-01-19 LK https://hdl.handle.net/10347/46841 UL https://hdl.handle.net/10347/46841 LA eng NO López-Durán, A., Martínez-Vispo, C., Suárez-Castro, D. et al. Self-efficacy and sex influences on the relationship between tobacco dependence and long-term abstinence: a moderated mediation approach. Curr Psychol 45, 265 (2026). https://doi.org/10.1007/s12144-025-08818-4 NO Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. DS Minerva RD 22 abr 2026