RT Dissertation/Thesis
T1 Exploring the molecular mechanisms of the human VGF-derived antidepressant neuropeptide TLQp-62 on neurogenesis
A1 Moutinho, Daniela Mesquita
K1 VGF
K1 TLQP-62
K1 Neurogenesis
AB VGF-derived neuropeptide TLQP-62 has antidepressant-like properties byincreasing hippocampal neurogenesis. This process and VGF levels were found to beimpaired in neuropsychiatric disorders.In the present study TLQP-62 was found to promote neurodifferentiation of thehuman SH-SY5Y cell line by enhancing the expression of several proteins involved incell cycle regulation, in oxidative stress, in energy metabolism and biosynthesis, and incytoskeletal organization, promoting neurite outgrowth. All those processes contributeto neurodevelopment and synaptic function. Human TLQP-62 receptor was identifiedas the G-protein coupled receptor OR5P3, promoting an increase in cAMP levels toinitiate signal transduction. TLQP-62 was also found to bind the HSPA8 chaperone.This neuropeptide 3D structure was also found to be mainly disordered but to betransitory with a C-term α-helix that might be stabilized by HSPA8 contributing to itsreceptor binding and activation.All together these data can contribute to the development of a possible TLQP-62receptor agonist to be used as a therapy for some neuropsychiatric disorders.
YR 2019
FD 2019
LK http://hdl.handle.net/10347/18376
UL http://hdl.handle.net/10347/18376
LA eng
DS Minerva
RD 26 abr 2026