RT Journal Article
T1 Serum activity of DPPIV and its expression on lymphocytes in patients with melanoma and in people with vitiligo
A1 Matić, Ivana Z.
A1 Đorđić, Marija
A1 Grozdanić, Nađa
A1 Damjanović, Ana
A1 Kolundžija, Branka
A1 Erić Nikolić, Aleksandra
A1 Džodić, Radan
A1 Šašić, Miomir
A1 Nikolić, Srđan
A1 Dobrosavljević, Danijela
A1 Rašković, Sanvila
A1 Andrejević, Slađana
A1 Gavrilović, Dušica
A1 Cordero Santamaría, Óscar Javier
A1 Juranić, Zorica D.
K1 CD26 expression
K1 DPPIV serum activity
K1 Melanoma
K1 Vitiligo
AB Background: Dipeptidyl peptidase IV, a multifunctional serine protease, is implicated in regulation of malignanttransformation, promotion and further progression of cancer, exerting tumor-suppressing or even completelyopposite - tumor-promoting activities.The aim of present research was to determine the serum DPPIV activity, as well as the percentages of CD26+lymphocytes, CD26+ overall white blood cells and the mean fluorescence intensity of CD26 expression onlymphocytes in patients with melanoma, people with vitiligo and in healthy controls.Methods: The activity of DPPIV in serum was determined by colorimetric test. Expression of DPPIV (as CD26) onimmunocompetent peripheral white blood cells was done using flow cytometry analysis.Results: Data from our study show for the first time statistically significant decrease: in the serum DPPIV activity, inthe percentage of CD26+ overall white blood cells and in the percentage of lymphocytes in patients withmelanoma in comparison to healthy control people. In addition, significantly lower serum DPPIV activity was foundin the group of patients with melanoma in relation to people with vitiligo too.Conclusion: This study indicates the need for exploring the cause and the importance of the disturbances in theserum DPPIV activity and in the CD26 expression on immunocompetent cells in complex molecular mechanismsunderlying the development and progression of melanoma
PB BMC
YR 2012
FD 2012
LK http://hdl.handle.net/10347/22081
UL http://hdl.handle.net/10347/22081
LA eng
NO Matić, I. Z., Đorđić, M., Grozdanić, N., Damjanović, A., Kolundžija, B., Erić-Nikolić, A., ... & Rašković, S. (2012). Serum activity of DPPIV and its expression on lymphocytes in patients with melanoma and in people with vitiligo. BMC immunology, 13(1), 48.
NO The authors are grateful to the Ministry of Education and Science of the Republic of Serbia for the financial support (Project 175011)
DS Minerva
RD 1 may 2026