RT Journal Article
T1 Are worry and rumination specific pathways linking neuroticism and symptoms of anxiety and depression in patients with generalized anxiety disorder, major depressive disorder and mixed anxiety-depressive disorder?
A1 Merino Madrid, Hipólito
A1 Senra Rivera, María del Carmen
A1 Ferreiro Díaz, Fátima
K1 Depression
K1 Anxiety
K1 Reflection
K1 Cognitive neurology
K1 Cognition
K1 Anxietty disorders
K1 Diagnostic medicine
K1 Patients
AB This study examines the relationships between neuroticism (higher-order vulnerability factor), the cognitive styles of worry, brooding and reflection (second-order vulnerability factors) and symptoms of anxiety and depression in three groups of patients: patients with Generalized Anxiety Disorder (GAD), with Major Depressive Disorder (MDD) and with Mixed Anxiety-Depressive Disorder (MADD). One hundred and thirty four patients completed a battery of questionnaires including measures of neuroticism, worry, rumination (brooding and reflection), anxiety and depression. Multiple mediation analyses indicate that worry may act as a mediating mechanism linking neuroticism and anxiety symptoms in the three diagnostic groups, whereas brooding-rumination may play a mediating role between neuroticism and depressive symptoms in patients with MDD and MADD and, with less certainty, in patients with GAD. Overall, our findings suggest that neuroticism may increase the risk of anxious and depressive symptoms via specific links involving either worry or brooding, respectively, and that both worry and brooding may operate in the three groups examined, irrespectively of whether anxiety or depression are the main emotions or whether they coexist without any clear predominance; consequently, we hypothesize the existence of "specific transdiagnostic" mechanisms
PB PLOS
SN 1932-6203
YR 2016
FD 2016-05
LK http://hdl.handle.net/10347/15706
UL http://hdl.handle.net/10347/15706
LA eng
NO Merino H, Senra C, Ferreiro F (2016) Are Worry and Rumination Specific Pathways Linking Neuroticism and Symptoms of Anxiety and Depression in Patients with Generalized Anxiety Disorder, Major Depressive Disorder and Mixed Anxiety-Depressive Disorder? PLoS ONE 11(5): e0156169. https://doi.org/10.1371/journal.pone.0156169
DS Minerva
RD 3 may 2026