RT Journal Article
T1 The Role of Partial Enteral Nutrition for Induction of Remission in Crohn’s Disease: A Systematic Review of Controlled Trials
A1 Gonzalez Torres, Lucía
A1 Moreno Álvarez, Ana
A1 Fernández Lorenzo, Ana Estefanía
A1 Leis Trabazo, María Rosaura
A1 Solar Boga, Alfonso
K1 Inflammatory bowel disease
K1 Crohn’s disease
K1 Nutritional therapy
K1 Enteral nutrition
K1 Diet
AB Exclusive enteral nutrition (EEN) is recommended as a first-line therapy to induce remission of Crohn’s disease (CD) and is considered as effective as corticosteroid treatment. However, the dietary restriction causes lack of adherence and poor tolerance to the therapy. Partial enteral nutrition (PEN), which allows for the ingestion of some food, could be a better tolerated alternative, but it is unknown whether it is as effective at inducing CD remission as EEN. The aim of this systematic review is to analyze the available evidence on PEN as a remission induction therapy in CD. A literature search was conducted using the MEDLINE (via PUBMED) and Cochrane Library databases following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Clinical trials in pediatric and adult patients were included. The risk of bias was assessed following the Cochrane Collaboration methodology. The selected studies showed variable but high response rates to PEN and EEN. Limitations regarding the wide heterogeneity between the studies included in this review should be considered. Although more studies are needed, according to our results, PEN combined with a highly restrictive diet seems to be as effective as EEN in inducing remission of CD.
PB MDPI
YR 2022
FD 2022-12-09
LK https://hdl.handle.net/10347/45431
UL https://hdl.handle.net/10347/45431
LA eng
NO González-Torres, L.; Moreno-Álvarez, A.; Fernández-Lorenzo, A.E.; Leis, R.; Solar-Boga, A. The Role of Partial Enteral Nutrition for Induction of Remission in Crohn’s Disease: A Systematic Review of Controlled Trials. Nutrients 2022, 14, 5263. https://doi.org/10.3390/ nu14245263
NO This research received no external funding. Professor Novoa Santos Foundation financially supported the publication of the article.
DS Minerva
RD 27 abr 2026