RT Journal Article
T1 Increased Endothelial Progenitor Cell Levels are Associated with Good Outcome in Intracerebral Hemorrhage
A1 Pías Peleteiro, Juan Manuel
A1 Pérez Mato, María
A1 López Arias, Esteban
A1 Rodríguez Yáñez, Manuel
A1 Blanco González, Miguel
A1 Campos Pérez, Francisco
A1 Castillo Sánchez, José Antonio
A1 Sobrino Moreiras, Tomás
K1 Prognostic markers
K1 Stroke
AB Circulating endothelial progenitor cells (EPCs) play a role in the regeneration of damaged brain tissue. However, the relationship between circulating EPC levels and functional recovery in intracerebral hemorrhage (ICH) has not yet been tested. Therefore, our aim was to study the influence of circulating EPCs on the outcome of ICH. Forty-six patients with primary ICH (males, 71.7%; age, 72.7 ± 10.8 years) were prospectively included in the study within 12 hours of symptom onset. The main outcome variable was good functional outcome at 12 months (modified Rankin scale ≤2), considering residual volume at 6 months as a secondary variable. Circulating EPC (CD34+/CD133+/KDR+) levels were measured by flow cytometry from blood samples obtained at admission, 72 hours and day 7. Our results indicate that patients with good outcome show higher EPC numbers at 72 hours and day 7 (all p < 0.001). However, only EPC levels at day 7 were independently associated with good functional outcome at 12 months (OR, 1.15; CI95%, 1.01–1.35) after adjustment by age, baseline stroke severity and ICH volume. Moreover, EPC levels at day 7 were negatively correlated to residual volume (r = −0.525; p = 0.005). In conclusion, these findings suggest that EPCs may play a role in the functional recovery of ICH patients.
PB Nature Publishing Group
YR 2016
FD 2016
LK http://hdl.handle.net/10347/22973
UL http://hdl.handle.net/10347/22973
LA eng
NO Pías-Peleteiro, J., Pérez-Mato, M., López-Arias, E. et al. Increased Endothelial Progenitor Cell Levels are Associated with Good Outcome in Intracerebral Hemorrhage. Sci Rep 6, 28724 (2016). https://doi.org/10.1038/srep28724
NO This study has been partially supported by grants from Instituto de Salud Carlos III (PI14/01879), SpanishResearch Network on Cerebrovascular Diseases RETICS-INVICTUS (RD12/0014), Xunta de Galicia (ConselleríaEducación GRC2014/027) and the European Union program FEDER. Furthermore, F. Campos (CP14/00154)and T. Sobrino (CP12/03121) are recipients of a research contract from Miguel Servet Program of Instituto deSalud Carlos III
DS Minerva
RD 29 abr 2026