RT Journal Article
T1 The Role of Dyads in Subjective Reporting and Prediction of Cognitive Worsening in Cognitively Unimpaired Individuals and Individuals with Subjective Cognitive Decline: Results of the CompAS Longitudinal Study
A1 Pérez Blanco, Lucía
A1 Nieto Vieites, Ana
A1 Felpete López, Alba
A1 Mallo López, Sabela Carme
A1 Arora, Sonali
A1 Lojo Seoane, Cristina
A1 Juncos Rabadán, Onésimo
A1 Pereiro Rozas, Arturo X.
K1 Dyad agreement
K1 Hypernosognosia
K1 Informant
K1 Longitudinal
K1 Subjective cognitive complaints
K1 Subjective cognitive decline
K1 Survival
AB Objective: The main aim was to examine the value of agreement on subjective cognitive complaints (SCCs) reported by study participants and informants in predicting worsening cognitive function over time in cognitively unimpaired (CU) and subjective cognitive decline (SCD) participants.Methods: The sample consisted of 175 participants from the CompAS study (CU = 139; SCD = 36), who were followed up three times along a period from 17 to 76 months after the start of the study. Levels of agreement on the "Dyadic SCCs" were categorized according to whether informant and participant scores at baseline on the short version of the "Questionnaire d'Autoevaluation de la Mémoire" were above or below a cut-off point accounting for age-related normative complaints. Two categories of agreement were identified: (a) participant scores above the cut-off and informant scores below the cut-off ("Self-over-reporting"); (b) both participant and informant scores above the cut-off point ("Agreement on presence"). We performed Cox proportional hazards regression model adjusted for sex, age, and years of education.Results: The tested model yielded statistical significant findings and acceptable model fit parameters. "Dyadic SCCs" significantly predicted cognitive worsening over time, with "Self-over-reporting" acting as a better indicator of the risk than "Agreement on presence" in both CU and SCD groups.Conclusions: The data showed that the "Self-overreporting," compared to "Agreement on presence," increases the risk of worsening per time unit. The findings may be explained by greater awareness of one's own difficulties (hypernosognosia) in preclinical stages of cognitive decline.
PB Oxford University Press
SN 0887-6177
YR 2025
FD 2025-12-15
LK https://hdl.handle.net/10347/45381
UL https://hdl.handle.net/10347/45381
LA eng
NO Pérez-Blanco, L., Nieto-Vieites, A., Felpete-López, A., Mallo, S. C., Arora, S., Lojo-Seoane, C., Juncos-Rabadán, O., & Pereiro, A. X. (2025). The Role of Dyads in Subjective Reporting and Prediction of Cognitive Worsening in Cognitively Unimpaired Individuals and Individuals with Subjective Cognitive Decline: Results of the CompAS Longitudinal Study. Archives of Clinical Neuropsychology, 00, 1–10. https://doi.org/10.1093/arclin/acaf114
NO Supported through FEDER funds (“A way to make Europe”) by the Spanish AEI (Do i: 10.13039/501100011033; Refs. PID2020-114521RB-C21 and PID2023-151659OB-C21) and bytheGalicianGovernment(ConselleríadeCultura,Educación e Ordenación Universitaria; axudas para a consolidación e estruturación de unidades de investigación competitivas do Sistema U niversitario de Galicia ED431C 2021/04; GI-1807- USC: Ref.2021-PG011).
DS Minerva
RD 23 abr 2026