RT Journal Article
T1 Response Inhibition and Binge Drinking During Transition to University: An fMRI Study
A1 Suárez Suárez, Samuel
A1 Doallo Pesado, Sonia
A1 Pérez García, José Manuel
A1 Corral Varela, María Montserrat
A1 Rodríguez Holguín, Socorro
A1 Cadaveira Mahía, Fernando
K1 Binge drinking
K1 Response inhibition
K1 Go/NoGo
K1 fMRI
K1 Neuroimaging
K1 Alcohol-related stimuli
K1 Consumo intensivo de alcohol
K1 Inhibición de resposta
K1 Neuroimaxe
K1 IRMf
K1 Estímulos asociados a alcohol
AB Background: Binge Drinking (BD), a highly prevalent drinking pattern among youth, has been linked with anomalies in inhibitory control. However, it is still not well characterized whether the neural mechanisms involved in this process are compromised in binge drinkers (BDs). Furthermore, recent findings suggest that exerting inhibitory control to alcohol-related stimuli requires an increased effort in BDs, relative to controls, but the brain regions subserving these effects have also been scarcely investigated. Here we explored the impact of BD on the pattern of neural activity mediating response inhibition and its modulation by the motivational salience of stimuli (alcohol-related content).Methods: Sixty-seven (36 females) first-year university students, classified as BDs (n = 32) or controls (n = 35), underwent fMRI as they performed an alcohol-cued Go/NoGo task in which pictures of alcoholic or non-alcoholic beverages were presented as Go or NoGo stimuli.Results: During successful inhibition trials, BDs relative to controls showed greater activity in the bilateral inferior frontal gyrus (IFG), extending to the anterior insula, a brain region usually involved in response inhibition tasks, despite the lack of behavioral differences between groups. Moreover, BDs displayed increased activity in this region restricted to the right hemisphere when inhibiting a prepotent response to alcohol-related stimuli.Conclusions: The increased neural activity in the IFG/insula during response inhibition in BDs, in the absence of behavioral impairments, could reflect a compensatory mechanism. The findings suggest that response inhibition-related activity in the right IFG/insula is modulated by the motivational salience of stimuli and highlight the role of this brain region in suppressing responses to substance-associated cues.
PB Frontiers Media
YR 2020
FD 2020
LK http://hdl.handle.net/10347/22915
UL http://hdl.handle.net/10347/22915
LA eng
NO Suárez-Suárez, S., Doallo, S., Pérez-García, J.M., Corral, M., Rodríguez Holguín, S., Cadaveira, F. (2020). Response Inhibition and Binge Drinking During Transition to University: An fMRI Study. Frontiers in Psychiatry, 11:535. doi: 10.3389/fpsyt.2020.00535
NO This investigation was supported by grants from the Spanish Ministerio de Sanidad, Servicios Sociales e Igualdad, Plan Nacional sobre Drogas (PNSD 2015/034), Ministerio de Economía y Competitividad (PSI2015-70525-P) co-funded for European Regional Development Fund and Xunta de Galicia (GRC ED431C 2017/06). SS-S was supported by a predoctoral fellowship from the Spanish Ministerio de Economía y Competitividad (BES-2016-076298). JP-G was supported by the FPU program from the Spanish Ministerio de Educación, Cultura y Deporte (FPU16/01573)
DS Minerva
RD 24 abr 2026