RT Journal Article
T1 Synthesis and Supramolecular Functional Assemblies of Ratiometric pH Probes
A1 Méndez Ardoy, Alejandro
A1 Reina Martín, Jose Juan
A1 Montenegro García, Javier
K1 Fluorescent probes
K1 Supramolecular Chemistry
K1 Organic synthesis
K1 Ratiometric probes
AB Tracking the pH with spatiotemporal resolution is a critical challenge for synthetic chemistry, chemical biology and beyond. Over the last decade different small probes and supramolecular systems have emerged for in celluloor in vivo pH tracking. However, pH reporting still presents critical limitations such as background reduction, sensor improved stability, cell targeting, endosomal escape, near and far infrared ratiometric pH tracking, adaptation to the new imaging techniques (i.e. super‐resolution), etc. These challenges will demand the combined efforts of synthetic and supramolecular chemistry working together to develop a next generation of smart materials that will resolve the current limitations. In this review we describe the recent advances in the synthesis of small fluorescent probes together with new supramolecular functional systems employed for pH tracking with emphasis in ratiometric probes. The combination of organic synthesis and stimuli‐responsive supramolecular functional materials will be essential to solve future challenges of pH tracking such as the improved signal to noise ratio, on target activation and microenvironment reporting
PB Wiley
SN 0947-6539
YR 2020
FD 2020
LK http://hdl.handle.net/10347/20678
UL http://hdl.handle.net/10347/20678
LA eng
NO Méndez-Ardoy, A., Reina, J..J. and Montenegro, J. (2020), Synthesis and Supramolecular Functional Assemblies of Ratiometric pH Probes. Chem. Eur. J.. doi:10.1002/chem.201904834
NO This work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [SAF2017-89890-R], the Xunta de Galicia (ED431C 2017/25, 2016-AD031 and Centro Singular de Investigación de Galicia accreditation 2016–2019, ED431G/09), the ISCIII (RD16/0008/003), and the European Union (European Regional Development Fund –ERDF). A.M. received a Marie Curie fellowship (GLYCONANOPEP-750248). J.M. received a Ramón y Cajal (RYC-2013-13784), an ERC Starting Investigator Grant (DYNAP-677786) and a Young Investigator Grant from the Human Frontier Science Research Program (RGY0066/2017)
DS Minerva
RD 28 abr 2026