RT Journal Article
T1 Soft Actuated Hybrid Hydrogel with Bioinspired Complexity to Control Mechanical Flexure Behavior for Tissue Engineering
A1 Rial Silva, Ramón
A1 Liu, Zhen
A1 Ruso Beiras, Juan Manuel
K1 Hydrogels
K1 Scaffolds
K1 Bionanoparticles
K1 Tissue engineering
K1 Mechanical properties
AB Hydrogels exhibit excellent properties that enable them as nanostructured scaffolds for soft tissue engineering. However, single-component hydrogels have significant limitations due to the low versatility of the single component. To achieve this goal, we have designed and characterized different multi-component hydrogels composed of gelatin, alginate, hydroxyapatite, and a protein (BSA and fibrinogen). First, we describe the surface morphology of the samples and the main characteristics of the physiological interplay by using fourier transform infrared (FT-IR), and confocal Raman microscopy. Then, their degradation and swelling were studied and mechanical properties were determined by rheology measurements. Experimental data were carefully collected and quantitatively analyzed by developing specific approaches and different theoretical models to determining the most important parameters. Finally, we determine how the nanoscale of the system influences its macroscopic properties and characterize the extent to which degree each component maintains its own functionality, demonstrating that with the optimal components, in the right proportion, multifunctional hydrogels can be developed
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23633
UL http://hdl.handle.net/10347/23633
LA eng
NO Rial, R.; Liu, Z.; Ruso, J.M. Soft Actuated Hybrid Hydrogel with Bioinspired Complexity to Control Mechanical Flexure Behavior for Tissue Engineering. Nanomaterials 2020, 10, 1302
NO The authors acknowledge Ministerio de Ciencia e Innovación (PID2019-111327GB-100) and Xunta de Galicia (ED41E2018/08)
DS Minerva
RD 24 abr 2026