RT Journal Article
T1 Global Gene Expression Characterization of Circulating Tumor Cells in Metastasic Castration-Resistant Prostate Cancer Patients
A1 León Mateos, Luis
A1 Abalo, Alicia
A1 Casas, Helena
A1 Anido, Urbano
A1 Rapado González, Óscar
A1 Vieito, María
A1 Suárez Cunqueiro, María Mercedes
A1 Gómez Tato, Antonio
A1 Abal Posada, Miguel
A1 López López, Rafael
A1 Muinelo Romay, Laura
K1 Circulating tumor cells (CTCs)
K1 Castration-resistant prostate cancer (CRPC)
K1 Expression arrays
K1 Tumor markers
AB Background: Current therapeutic options in the course of metastatic castration-resistant prostate cancers (mCRPC) reinforce the need for reliable tools to characterize the tumor in a dynamic way. Circulating tumor cells (CTCs) have emerged as a viable solution to the problem, whereby patients with a variety of solid tumors, including PC, often do not have recent tumor tissue available for analysis. The biomarker characterization in CTCs could provide insights into the current state of the disease and an overall picture of the intra-tumor heterogeneity. Methods: in the present study, we applied a global gene expression characterization of the CTC population from mCRPC (n = 9), with the goal to better understand the biology of these cells and identify the relevant molecules favoring this tumor progression. Results: This analysis allowed the identification of 50 genes specifically expressed in CTCs from patients. Six of these markers (HOXB13, QKI, MAOA, MOSPD1, SDK1, and FGD4), were validated in a cohort of 28 mCRPC, showing clinical interest for the management of these patients. Of note, the activity of this CTC signature was related to the regulation of MYC, a gene strongly implicated in the biology of mCRPC. Conclusions: Overall, our results represent new evidence on the great value of CTCs as a non-invasive biopsy to characterize PC
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23855
UL http://hdl.handle.net/10347/23855
LA eng
NO León-Mateos, L.; Abalo, A.; Casas, H.; Anido, U.; Rapado-González, Ó.; Vieito, M.; Suárez-Cunqueiro, M.; Gómez-Tato, A.; Abal, M.; López-López, R.; Muinelo-Romay, L. Global Gene Expression Characterization of Circulating Tumor Cells in Metastasic Castration-Resistant Prostate Cancer Patients. J. Clin. Med. 2020, 9, 2066
NO This work was partially financed with the “liquid Biopsy crowdfunding, 2017”. L.M-L. is supported by AECC
DS Minerva
RD 24 abr 2026