RT Journal Article
T1 Longitudinal relationship of liver injury with inflammation biomarkers in COVID-19 hospitalized patients using a joint modeling approach
A1 Díaz Louzao, Carla
A1 Barrera López, Lucía
A1 López Rodríguez, María
A1 Casar Cocheteux, Clara
A1 Vázquez Agra, Néstor
A1 Pernas Pardavila, Hadrián
A1 Marqués Afonso, Ana
A1 Vidal Vázquez, Martín
A1 Montoya, Jonathan G.
A1 Andrade, Ariadna H.
A1 Fernández Castro, Iván
A1 Varela García, Pablo Manuel
A1 González Quintela, Arturo
A1 Otero Antón, Esteban
A1 Gude Sampedro, Francisco
A1 Cadarso Suárez, Carmen María
A1 Tomé, Santiago
K1 Hepatology
K1 Viral infection
AB The mechanisms underlying liver disease in patients with COVID-19 are not entirely known. The aim is to investigate, by means of novel statistical techniques, the changes over time in the relationship between inflammation markers and liver damage markers in relation to survival in COVID-19. The study included 221 consecutive patients admitted to the hospital during the first COVID-19 wave in Spain. Generalized additive mixed models were used to investigate the influence of time and inflammation markers on liver damage markers in relation to survival. Joint modeling regression was used to evaluate the temporal correlations between inflammation markers (serum C-reactive protein [CRP], interleukin-6, plasma D-dimer, and blood lymphocyte count) and liver damage markers, after adjusting for age, sex, and therapy. The patients who died showed a significant elevation in serum aspartate transaminase (AST) and alkaline phosphatase levels over time. Conversely, a decrease in serum AST levels was observed in the survivors, who showed a negative correlation between inflammation markers and liver damage markers (CRP with serum AST, alanine transaminase [ALT], and gamma-glutamyl transferase [GGT]; and D-dimer with AST and ALT) after a week of hospitalization. Conversely, most correlations were positive in the patients who died, except lymphocyte count, which was negatively correlated with AST, GGT, and alkaline phosphatase. These correlations were attenuated with age. The patients who died during COVID-19 infection displayed a significant elevation of liver damage markers, which is correlated with inflammation markers over time. These results are consistent with the role of systemic inflammation in liver damage during COVID-19
PB Nature
SN 2045-2322
YR 2022
FD 2022
LK http://hdl.handle.net/10347/30191
UL http://hdl.handle.net/10347/30191
LA eng
NO Diaz-Louzao, C., Barrera-Lopez, L., Lopez-Rodriguez, M. et al. Longitudinal relationship of liver injury with inflammation biomarkers in COVID-19 hospitalized patients using a joint modeling approach. Sci Rep 12, 5547 (2022). https://doi.org/10.1038/s41598-022-09290-x
DS Minerva
RD 27 abr 2026