RT Dissertation/Thesis
T1 Therapeutical approaches for prion diseases and characterization of recombinant prion strains from different perspectives
A1 López Lorenzo, Nuria
K1 Prion diseases
K1 treatment
K1 amyloid
K1 prion strains
AB Prion diseases are rare and fatal neurodegenerative disordersfor which there is no cure or treatment. They are caused byinfectious proteins that result from the misfolding of thecellular prion protein, PrPC, into its pathogenic form, PrPSc.Furthermore, PrPSc can appear as conformational variantscalled strains that exhibit distinct phenotypes and couldpresent resistance to anti-prion compounds.This thesis aims to assess three different therapeuticcandidates in a fast murine model of prion disease to tacklethese disorders from different aspects of their biology.Additionally, due to the role of prion strains in drug resistanceand their biochemical and structural interest, diverserecombinant prion strains were characterized in this thesisusing biological, biochemical, and biophysical methods.
YR 2023
FD 2023
LK http://hdl.handle.net/10347/32540
UL http://hdl.handle.net/10347/32540
LA eng
DS Minerva
RD 24 abr 2026