RT Dissertation/Thesis T1 Circulating tumor cells in metastatic colorectal cancer from basic understandig to clinical practice A1 Barbazán García, Jorge A2 Universidade de Santiago de Compostela. Facultade de Bioloxía. Facultade de Medicina e Odontoloxía. Departamento de Medicina. Laboratorio de Oncoloxía Médica Traslacional, K1 Colorectal cancer (CRC) K1 Circulating tumor cells (CTCs) K1 metastasis AB Colorectal cancer (CRC) represents the third most diagnosed cancer type worldwide,accounting for more than 600.000 deaths in 2012, which approximately represents 8,5% of allcancer-related deaths. It arises from the inner intestinal layer, usually from preexisting polypsthat, after a series of molecular and genetic alterations, finally generate colorectal tumors. It isvery important to consider that in CRC patients, the appearance of cancer metastasis, tumormasses that originate from primary tumors at distant sites, strongly determine patient prognosis.Only 8-10% of patients diagnosed with CRC at advanced stages survive after five years offollow up, which reinforces the importance of metastasis research to improve patientmanagement and survival rates in CRC. YR 2014 FD 2014-09-03 LK http://hdl.handle.net/10347/11431 UL http://hdl.handle.net/10347/11431 LA eng DS Minerva RD 24 abr 2026