RT Journal Article
T1 Nestin Expression Is Associated with Relapses in Head and Neck Lesions
A1 Pérez-Sayáns García, Mario
A1 Chamorro Petronacci, Cintia Micaela
A1 Baltazar, Fatima
A1 Pires, Fábio Ramoa
A1 Insua Brandariz, Ángel
A1 Suárez Quintanilla, Juan
A1 Suárez Peñaranda, José Manuel
K1 Head and neck neoplasms
K1 Nestin
K1 Immunohistochemistry
K1 Recurrence
AB Background: The aim was to investigate the clinical significance of nestin immunohistochemical expression in head and neck area lesions and to study its role in patient survival and recurrence. Methods: 39 (44.3%) nasosinus, 37 (42%) major salivary gland (6 submandibular and 31 parotid) and 12 (13.6%) oral cavity lesions of paraffin-embedded samples were retrospectively included. Results: The expression was categorized into grades, negative for 55 (62.5%) cases, grade 1 in 10 cases (11.4%), grade 2 in 12 cases (13.6%), and grade 3 in 11 cases (12.5%); 100% of pleomorphic adenomas were positive for nestin with grade 3 intensity, 100% of polyps and inverted papillomas were negative (p < 0.001). The lowest estimate of disease-free-survival (DFS) was for grade 1 expression, with 50 months, confidence interval (CI): 95% 13.3–23.9 months and the highest for grade 3 expression, 167.9 months (CI: 95% 32.1–105 months; Log-Rank = 14.846, p = 0.002). ROC (receiver operating characteristic) curves revealed that the positivity for nestin (+/−) in relation to malignancy, presented a sensitivity of 50.98%, a specificity of 81.08%, with an area under the curve of 0.667 (p = 0.009). Conclusions: Nestin could be a useful marker to detect the presence of stem cells in head and neck tumors that have a role in tumor initiation and progression
PB MDPI
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26689
UL http://hdl.handle.net/10347/26689
LA eng
NO Diagnostics 2021, 11(4), 583; https://doi.org/10.3390/diagnostics11040583
DS Minerva
RD 28 abr 2026