RT Journal Article
T1 Brain microstructure alterations in subjective cognitive decline: a multi-component T2 relaxometry study
A1 Rivas Fernández, Miguel Ángel
A1 Bouhrara, Mustapha
A1 Canales Rodríguez, Erick Jorge
A1 Lindín Novo, Mónica
A1 Zurrón Ocio, Montserrat
A1 Díaz Fernández, Fernando
A1 Galdo Álvarez, Santiago
K1 Intra-extracellular water fraction
K1 Myelin content
K1 Neuroinflammation
K1 Neuromicrostructural tissue integrity
AB Previous research has revealed patterns of brain atrophy in subjective cognitive decline, a potential preclinical stage of Alzheimer's disease. However, the involvement of myelin content and microstructural alterations in subjective cognitive decline has not previously been investigated. This study included three groups of participants recruited from the Compostela Aging Study project: 53 cognitively unimpaired adults, 16 individuals with subjective cognitive decline and hippocampal atrophy and 70 with subjective cognitive decline and no hippocampal atrophy. Group differences were analysed across five MRI biomarkers derived from multi-component T2 relaxometry, each sensitive to variations in cerebral composition and microstructural tissue integrity. Although no significant differences in myelin content were observed between groups, the subjective cognitive decline with hippocampal atrophy group exhibited a larger free-water fraction, and reduced fraction and relaxation times of the intra/extracellular water compartment in frontal, parietal and medial temporal lobe brain regions and white matter tracts as compared with the other groups. Moreover, both subjective cognitive decline groups displayed lower total water content as compared with the control group and the subjective cognitive decline with hippocampal atrophy group showed lower total water content as compared with the subjective cognitive decline without hippocampal atrophy group. These changes are likely related to microstructural tissue differences related to neuroinflammation, axonal degeneration, iron accumulation or other physiologic variations, calling for further examinations.
PB Oxford University Press
YR 2025
FD 2025-02-16
LK https://hdl.handle.net/10347/42555
UL https://hdl.handle.net/10347/42555
LA eng
NO Rivas-Fernández, M. Á., Bouhrara, M., Canales-Rodríguez, E. J., Lindín, M., Zurrón, M., Díaz, F., & Galdo-Álvarez, S. (2025). Brain microstructure alterations in subjective cognitive decline: a multi-component T2 relaxometry study. Brain communications, 7(1), fcaf017. https://doi.org/10.1093/braincomms/fcaf017
NO This study was supported by grants from the Ministerio de Economía y Competitividad, Spain (References: PSI2014-55316-C3-3-R; PSI2017-89389-C2-2-R; and PID2020-114521RB-C21/C22) and the Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia (References: ED431-2017/27 and ED431C-2021/04). All with European Regional Development Funds.
DS Minerva
RD 26 abr 2026