RT Journal Article
T1 Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer
A1 Fernández Campos, Francisco
A1 Navarro, Francesc
A1 Corrales, Adrian
A1 Picas, Jordi
A1 Pena, Eloy
A1 González, Jordi
A1 Otero Espinar, Francisco Javier
K1 Nail lacquers
K1 Cyclodextrins
K1 Methylsulfonylmethane
K1 Active penetration
K1 Biotin
AB A new cyclodextrin polypseudorotaxanes nail lacquer (Regenail®) containing biotin, methyl sulphonyl methane (MSM), and dimethylsilanediol salicylate was developed and evaluated in vitro and in vivo. The product was developed to improve nail status and diminish signs of pathological nail alterations. A reference product (Betalfatrus®) was used for comparative purposes. An in vitro permeation experiment in hooves showed high MSM and biotin absorption. The content of sulfur and silicon in hooves was also found to be higher compared with the reference product. MSM was tested in human keratinocytes, exhibiting a good cytotoxicity profile and anti-inflammatory activity by the reduction in IL-8 and TNF-α under LPS stimuli. A clinical study was performed to check product safety and efficacy against nail brittleness and alterations such as Beau’s lines and onychorrhexis. A reduction in both alterations and in surface roughness without alteration of nail structure was observed, with a good level of patient acceptance and satisfaction
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23615
UL http://hdl.handle.net/10347/23615
LA eng
NO Fernández-Campos, F.; Navarro, F.; Corrales, A.; Picas, J.; Pena, E.; González, J.; Otero-Espinar, F.J. Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer. Pharmaceutics 2020, 12, 730
DS Minerva
RD 24 abr 2026