RT Journal Article T1 Uncovering optimal biorefinery designs for agricultural waste: Insights from superstructure optimization under uncertainty A1 Hauwaert, Lucas van der A1 Regueira López, Alberte A1 Zondervan, Edwin A1 Mauricio Iglesias, Miguel K1 Superstructure optimization K1 Stochastic optimization K1 Early-stage biorefinery design K1 OUTDOOR K1 Agricultural waste management AB This study explores the application of superstructure optimization to guide early-stage biorefinery design decisions under uncertainty. A case study on processing agricultural waste (potato peel waste) demonstrates the method's capacity to identify economically viable and robust pathways from two perspectives: waste owners and stakeholders invested in emerging technologies. For waste owners, stochastic optimization revealed that converting potato peel waste into animal feed is the most robust and economically attractive pathway, achieving an expected profit of 61.2 €/t of waste with minimal risk exposure. For technology developers, global sensitivity analysis of a polyhydroxyalkanoate (PHA) production route highlighted critical parameters for improvement, including PHA extraction yield and separation efficiency, to enhance economic performance and outcompete alternative production routes. The work includes enhancements to the OUTDOOR software, integrating uncertainty optimization and sensitivity analysis, to provide a comprehensive framework for evaluating design alternatives. This structured approach facilitates the identification of robust biorefinery configurations in the early design stage. It also allows stakeholders in emerging technologies to benchmark their processes against alternative designs, thereby identifying critical parameters for optimization PB Elsevier YR 2025 FD 2025 LK https://hdl.handle.net/10347/43784 UL https://hdl.handle.net/10347/43784 LA eng NO Van der Hauwaert, L., Regueira, A., Zondervan, E., & Mauricio-Iglesias, M. (2025). Uncovering optimal biorefinery designs for agricultural waste: Insights from superstructure optimization under uncertainty. Journal of Environmental Management, 394, 127551. https://10.1016/j.jenvman.2025.127551 NO This project (AGRILOOP) has received funding from the European Union's Horizon Europe research and innovation programme and the UK Research and Innovation fund under the UK government's Horizon Europe funding guarantee, grant agreement No. 101081776. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them. https://agriloop-project.eu/. Lucas Van der Hauwaert acknowledges CRETUS for supporting his research stay at the Institute Sustainable Process Technology (SPT) at the University of Twente. The Authors would also like to acknowledge the help of Benyamin Khoshnevisan and Mias Sommer Schjønberg from SDU+, Lionel Nguemna, Angela Marchetti and Mariana Villano from UNIROMA, Jan Broeze and Marta Rodrigues Illera from Wageningen Research, Angel Estevez Alonso from UGent, Annalisa Tassoni from UNIBO, Jan Linck from Ecozept, Alice Charpigny from DSS+, Diana Molina Delgado from FCAC, Aleksandra Zderic from Avebe and Michael Pil from AVECOM for their inputs and suggestions for the superstructure DS Minerva RD 4 may 2026