RT Dissertation/Thesis
T1 Polysaccharide functionalised span nanoparticles as gene delivery systems. Application in the treatment of colorectal liver metastasis
A1 Fernández Piñeiro, Inés
K1 Nanoparticles
K1 Gene therapy
K1 Polysaccharides
K1 microRNA
AB The main objective of this work has been the design of a new polysaccharide functionalised nanosystem as a non-viral microRNA vector for the treatment of liver metastasis from colorectal cancer. For this purpose, we modified our previously developed span nanoparticles using polysaccharides with endothelial targeting properties and studied their ability to act as gene delivery systems. Finally, we provide an in vivo proof-of-concept of the clinical potential of these nanoparticles as a novel microRNA-based therapeutic strategy for cancer treatment.
YR 2018
FD 2018
LK http://hdl.handle.net/10347/16634
UL http://hdl.handle.net/10347/16634
LA eng
DS Minerva
RD 24 abr 2026