RT Dissertation/Thesis
T1 Transition Metal-Catalyzed Annulations in Biological Media
A1 Miguel Ávila, Joan
K1 Química bioortogonal
K1 metales de transición
K1 cicloadición
K1 fotoquímica
AB As the smallest unit of life, cell has been widely explored since his discoveryin the sixties. Like chemists, chemical biology allows us the application of synthetic small molecules for the study oflife. Since the recent incorporation of bioorthogonal reactions as new tools for cell research, chemical biology hasbeen boosted, revolutionizing closely related fields like imaging, drug development or biotechnology due to itsability to manipulate small exogenous compounds inside living systems without disturbing the host metabolism.During this PhD thesis, we have explored the potential of organometallic chemistry in the bioorthogonal field. Wehave discovered that predefined Cu(I) complexes promote intracellular CuAAC with high efficiency. Moreover, Ru[2+2+2] cycloaddition has been successfully employed for the intracellular synthesis of biomolecules in specificorganelles. Finally, the use of light has been investigated in the Meerwein arylation, that proceeds with excellentchemoselectively and yields in biological settings.
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29299
UL http://hdl.handle.net/10347/29299
LA eng
DS Minerva
RD 24 abr 2026