RT Journal Article
T1 Polyurethanes as new excipients in nail therapeutics
A1 Gregorí Valdes, Barbara S.
A1 Serro, Ana Paula
A1 Marto, Joana
A1 Santos, Rui Galhano dos
A1 Cutrín Gómez, Elena
A1 Otero Espinar, Francisco Javier
A1 Bordado, João Moura
A1 Ribeiro, Helena Margarida
K1 Nail lacquers
K1 Polyurethane
K1 Onychomycosis
K1 Topical treatment
K1 Terbinafine hydrochloride
K1 Ciclopirox olamine
AB Onychomycosis affects about 15% of the population. This disease causes physical and psychosocial discomfort to infected patients. Topical treatment (creams, solutions, gels, colloidal carriers, and nail lacquers) is usually the most commonly required due to the high toxicity of oral drugs. Currently, the most common topical formulations (creams and lotions) present a low drug delivery to the nail infection. Nail lacquers appear to increase drug delivery and simultaneously improve the effectiveness of treatment with increased patient compliance. These formulations leave a polymer film on the nail plate after solvent evaporation. The duration of the film residence in the nail constitutes an important property of nail lacquer formulation. In this study, a polyurethane polymer was used to delivery antifungals drugs, such as terbinafine hydrochloride (TH) and ciclopirox olamine (CPX) and the influence of its concentration on the properties of nail lacquer formulations was assessed. The nail lacquer containing the lowest polymer concentration (10%) was the most effective regarding the in vitro release, permeation, and antifungal activity. It has also been demonstrated that the application of PU-based nail lacquer improves the nail plate, making it smooth and uniform and reduces the porosity contributing to the greater effectiveness of these vehicles. To conclude, the use of polyurethane in nail formulations is promising for nail therapeutics
PB MDPI
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22547
UL http://hdl.handle.net/10347/22547
LA eng
NO Valdes, B.S.G.; Serro, A.P.; Marto, J.; Galhano dos Santos, R.; Cutrín Gómez, E.; Otero-Espinar, F.J.; Moura Bordado, J.; Margarida Ribeiro, H. Polyurethanes as New Excipients in Nail Therapeutics. Pharmaceutics 2018, 10, 276
NO This research was funded by FCT—Fundação para a Ciência e Tecnologia under grants SFRH/BD/78962/2011, SFRH/BPD/105662/2015 and a grant to iMed.ULisboa (UID/DTP/04138/2013)
DS Minerva
RD 3 may 2026