RT Journal Article
T1 Organometallic catalysis in aqueous and biological environments: harnessing the power of metal carbenes
A1 Gutiérrez Hernández, Sara
A1 Tomás Gamasa, María
AB Translating the power of transition metal catalysis to the native habitats of enzymes can significantly expand the possibilities of interrogating or manipulating natural biological systems, including living cells and organisms. This is especially relevant for organometallic reactions that have shown great potential in the field of organic synthesis, like the metal-catalyzed transfer of carbenes. While, at first sight, performing metal carbene chemistry in aqueous solvents, and especially in biologically relevant mixtures, does not seem obvious, in recent years there has been a growing number of reports demonstrating the feasibilityof the task. Either using small molecule metal catalysts or artificial metalloenzymes, a number of carbene transfer reactions that tolerate aqueous and biorelevant media are being developed. This review intends to summarize the most relevant contributions, and establish the state of the art in this emerging research field
PB Royal Society of Chemistry
YR 2022
FD 2022
LK http://hdl.handle.net/10347/28827
UL http://hdl.handle.net/10347/28827
LA eng
NO Chem. Sci., 2022, 13, 6478-6495
DS Minerva
RD 25 abr 2026